Molecular and genetic basis of colistin resistance in Acinetobacter baumannii

鲍曼不动杆菌粘菌素耐药性的分子和遗传基础

• 批准号: nhmrc : 546073
• 负责人: A/Pr John Boyce
• 金额: $ 35.13万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-genetic-basis-acinetobacter-baumannii/82142
• 关键词: Molecular; genetic; basis; colistin; resistance

Acinetobacter baumannii is a bacterium that causes hospital acquired infections which have become difficult to treat due to the bacteria developing resistance to most antibiotics in routine use. Colistin is now widely used as 'salvage' therapy in patients with these infections. Colistin resistance is currently low but is an emerging problem. As a first step in combating this problem this project will identify how this bacterium becomes resistant to colistin.

鲍氏不动杆菌是一种引起医院获得性感染的细菌，由于细菌对常规使用的大多数抗生素产生耐药性，医院获得性感染变得难以治疗。粘菌素现在被广泛用作这些感染患者的“挽救”治疗。粘菌素耐药性目前较低，但这是一个新出现的问题。作为解决这一问题的第一步，该项目将确定这种细菌如何对粘菌素产生耐药性。