How Burkholderia pseudomallei subverts host ubiquitination and autophagy pathways

鼻疽伯克霍尔德杆菌如何颠覆宿主泛素化和自噬途径

• 批准号: nhmrc : 1043667
• 负责人: A/Pr John Boyce
• 金额: $ 31.49万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/burkholderia-pseudomallei-subverts-autophagy-pathways/111592
• 关键词: How; Burkholderia; pseudomallei; subverts; host

Burkholderia pseudomallei is a bacterial organism found in soil and water that is the causative agent of melioidosis, a serious invasive disease of humans and animals occurring in tropical areas including northern Australia. Mortality is high owing to only limited treatment options being available. By defining the molecular mechanisms how B. pseudomallei evades removal from infected cells, we aim to identify specific bacterial targets that may form the basis of future prevention strategies.

类鼻疽伯克霍尔德氏菌是一种在土壤和水中发现的细菌有机体，是类鼻疽病的病原体，类鼻疽病是一种在包括澳大利亚北方在内的热带地区发生的严重的人类和动物侵袭性疾病。死亡率很高，原因是可供选择的治疗方法有限。通过定义B.由于类鼻疽逃避从受感染细胞中清除，我们的目标是确定可能构成未来预防策略基础的特定细菌靶点。