Intracellular survival of Burkholderia pseudomallei and evasion of autophagy

鼻疽伯克霍尔德氏菌在细胞内的存活和自噬的逃避

• 批准号: nhmrc : 545855
• 负责人: A/Pr John Boyce
• 金额: $ 30.06万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/intracellular-survival-burkholderia-evasion-autophagy/95086
• 关键词: Intracellular; survival; Burkholderia; pseudomallei; evasion

Melioidosis is a disease with high mortality that is caused by the bacterium Burkholderia pseudomallei. Autophagy is a natural part of the mammalian immune system. This project seeks to explain how Burkholderia pseudomallei avoids killing by host autophagy and identify the bacterial factors necessary for its survival within cells. The identified genes will be future targets for medical intervention.

类鼻疽病是由假鼻疽伯克霍尔德氏菌引起的一种死亡率很高的疾病。自噬是哺乳动物免疫系统的自然组成部分。该项目旨在解释假鼻疽伯克霍尔德氏菌如何避免通过宿主自噬而死亡，并确定其在细胞内生存所必需的细菌因素。已确定的基因将成为未来医疗干预的目标。