HB-EGF promotes recovery from experimental acute renal failure

HB-EGF 促进实验性急性肾衰竭的恢复

• 批准号: nhmrc : 114408
• 负责人: Prof David Power
• 金额: $ 22.5万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hb-egf-promotes-renal-failure/82794
• 关键词: HB; EGF; promotes; recovery; experimental

Kidney failure is a frequent complication of serious injury or illness. Although the kidneys generally recover, this can take some time. Before they recover, the inability of the kidneys to function normally adds significantly to the suffering and debility of these sick people. The question we wish to ask is how do the kidneys repair themselves? Ultimately, we would like to know how we could speed up this process. It seems that the kidney remodels after injury by increasing production of growth factors, which are specialised proteins that tell the kidney cells what to do. If we could determine which of these was the most important then it might be possible to give it to patients. If we could even find out how these growth facotrs work, then it might be possible to replace them with a drug that could be more easily administered than a protein.

肾衰竭是严重损伤或疾病的常见并发症。虽然肾脏通常会恢复，但这可能需要一段时间。在他们康复之前，肾脏无法正常发挥功能大大增加了这些病人的痛苦和虚弱。我们想问的问题是肾脏是如何自我修复的？最后，我们想知道如何加快这一进程。似乎肾脏在受伤后通过增加生长因子的产生来进行重建，生长因子是一种专门的蛋白质，告诉肾脏细胞该做什么。如果我们能确定哪一个是最重要的，那么就有可能把它给病人。如果我们能发现这些生长因子是如何工作的，那么就有可能用一种比蛋白质更容易服用的药物来代替它们。