Protein kinases regulate salt reabsorption in the kidney

蛋白激酶调节肾脏的盐重吸收

• 批准号: nhmrc : 434109
• 负责人: Prof David Power
• 金额: $ 35.45万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/protein-kinases-regulate-reabsorption-kidney/82384
• 关键词: Protein; kinases; regulate; salt; reabsorption

This proposal is designed to determine how the kidney senses the level of salt in the body and monitors blood pressure. This is critical for diseases such as hypertension, kidney and heart failure, where salt is retained inappropriately. We propose that the kidney uses proteins called kinases that are activated by salt in the kidney. When it is too low, they detect this and cause the kidney to absorb more salt to correct the deficiency. The way that they are able to do this has profound implications for human heart and kidney disease, and biology in general.

这项建议旨在确定肾脏如何感知体内的盐分水平并监测血压。这对高血压、肾脏和心力衰竭等疾病至关重要，因为在这些疾病中，盐被不当保留。我们认为肾脏使用的是一种被肾脏中的盐激活的称为激酶的蛋白质。当它太低时，他们会检测到这一点，并导致肾脏吸收更多的盐分来纠正这种不足。它们能够做到这一点的方式对人类心脏和肾脏疾病以及整个生物学都有深远的影响。