AMP-activated protein kinase (AMPK) in acute renal failure

急性肾衰竭中的 AMP 激活蛋白激酶 (AMPK)

• 批准号: nhmrc : 365225
• 负责人: Prof David Power
• 金额: $ 26.77万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/amp-activated-protein-renal-failure/100551
• 关键词: AMP; activated; protein; kinase; AMPK

Acute renal failure is a common complication of any severe illness. Generally, it is the lack of blood flow, or food that leads to this problem. People who are ill are unable to provide adequate blood flow to their kidneys, so the kidneys become diseased and fail to function. This can be fatal. There are, however, mechanisms in the kidney that are designed to avoid this shortage of energy. The aim of these studies is to find out what these protective mechanisms usually do in the kidney, and understand why they are not more active. We hope to find ways to switch them on earleir, using drugs, so as to protect the kidneys from injury.

急性肾功能衰竭是任何严重疾病的常见并发症。一般来说，是血液流动或食物的缺乏导致了这个问题。生病的人无法为肾脏提供足够的血液流动，因此肾脏会出现疾病并无法发挥作用。这可能是致命的。然而，肾脏中有一些机制旨在避免这种能量短缺。这些研究的目的是找出这些保护机制通常在肾脏中起什么作用，并了解为什么它们不更活跃。我们希望找到使用药物来打开耳机的方法，以保护肾脏免受伤害。