Regulation of SPAK by AMPK links salt reabsorption to energy metabolism

AMPK 对 SPAK 的调节将盐重吸收与能量代谢联系起来

• 批准号: nhmrc : 1006517
• 负责人: Prof David Power
• 金额: $ 35万
• 依托单位: Institute for Breathing and Sleep
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-spak-ampk-energy-metabolism/109189
• 关键词: Regulation; SPAK; AMPK; links; salt

Excessive salt and energy intake have emerged as major features of the unhealthy fast-food culture. Salt promotes high blood pressure, whereas high energy intakes increase obesity and diabetes. In this study, we aim to determine how energy availability and salt handling are linked in the kidney. This research will lead to new ways to treat high blood pressure by limiting salt reabsorption in the kidney.

过量的盐和能量摄入已经成为不健康快餐文化的主要特征。盐会导致高血压，而高能量摄入会增加肥胖和糖尿病。在这项研究中，我们的目标是确定肾脏中的能量可用性和盐处理是如何联系在一起的。这项研究将带来通过限制盐在肾脏中的重吸收来治疗高血压的新方法。