A PROBABILISTIC REFERENCE SYSTEM FOR THE HUMAN BRAIN: PET

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。目的：本项目的具体目标是开发一种用于人脑的数字概率参考系统。来自父方案的受试者将被邀请参加本方案。拟议研究的目的是获得规范的PET FDG数据，这将有利于其他在疾病状态下进行FDG PET的研究。研究计划和方法：将邀请来自父方案的50名受试者参加本PET成像方案。受试者将进行FDG PET测试。扫描预计需要1.5-2小时。临床相关性：本提案是NIH资助的P20第9年资助的补充。前五年获得了18-40岁受试者的解剖数据。目前的资助周期是获取40岁以上受试者的解剖和功能数据。父协议正在获取功能激活数据。目前提出的方案旨在获得静息状态葡萄糖代谢来确定神经元密度。在这项研究中获得的初步数据将用于向美国国立卫生研究院老龄化研究所提交拨款。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: This project has the specific goal of developing a digital probabilistic reference system for the human brain. Subjects from the parent protocol will be invited to enroll in this protocol. The purpose of the proposed study is to obtain normative PET FDG data, which will benefit other studies doing FDG PET in disease states. RESEARCH PLAN AND METHODS: Fifty subjects from the parent protocol will be invited to enroll in this PET imaging protocol. Subjects will have a FDG PET. Scans are expected to take 1.5-2 hours. CLINICAL RELEVANCE: This proposal is a supplement to a NIH funded P20 in its ninth year of funding. The first five years acquired anatomical data on subjects ages 18-40. The current funding cycle is acquiring anatomical and functional data on subjects over 40. The parent protocol is acquiring functional activation data. The current proposed protocol seeks to obtain resting state glucose metabolism to determine neuronal density. The preliminary data that will be acquired in this study will be used in a grant submission to the NIH aging institute.