REDUCED PHOSPHATE INTAKE IN "NORMO-PHOSPHATEMIC" CHRONIC KIDNEY DISEASE PATIENTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项建议的目的是(1)确立即使没有高磷血症，磷酸盐负荷在继发性甲状旁腺功能亢进症发生中的首要地位，以及(2)建立操纵磷酸盐负荷的治疗策略的初步数据，以努力通过增加内源性骨化三醇水平来改善继发性甲状旁腺功能亢进症的发展，骨化三醇本身以及磷酸盐水平的降低可能是潜在的生存因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purposes of this proposal are to (1) establish the primacy of phosphate loading, even without hyperphosphatemia, in the development of secondary hyperparathyroidism and (2) develop pilot data of a treatment strategy that manipulates phosphate loading in an effort to ameliorate the development of secondary hyperparathyroidism by increasing endogenous calcitriol levels, which itself along with decreased phosphate levels may be potential survival factors.