SECONDARY PREVENTION OF SMALL SUBCORTICAL STROKES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。确定脑小动脉疾病的有效治疗方法及其两种最常见的临床表现：皮质下小中风和认知能力下降。减少卒中复发和认知能力下降的最佳抗血小板治疗和降压管理尚未确定，可能会产生重要的健康益处。虽然mri定义的在没有手术可适应的颈动脉狭窄和主要危险心脏栓塞源的情况下症状性小皮质下卒中是参与研究的合格事件，复发性卒中是主要结局，但研究的目标范围更广，包括评估和预防血管性痴呆。本研究将为无动脉内膜切除术或抗凝指征的患者确定预防卒中复发和认知能力下降的最佳治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Define the efficacious therapies for cerebral small artery disease and its two most common clinical manifestations: small subcortical strokes and cognitive decline. Optimal antiplatelet therapy and antihypertensive management of patients to reduce stroke recurrence and cognitive decline has not been defined and is likely to yield important health benefits. Although MRI-defined symptomatic small subcortical strokes in the absence of surgically amenable cervical carotid stenosis and major-risk cardioembolic sources is the qualifying event for participation in the study and recurrent stroke is the primary outcome, the goals of the study are broader in scope and include assessment and prevention of vascular dementia. This study will define optimal treatment to prevent recurrent stroke and cognitive decline for patients without an indication for endarterectomy or anticoagulation.