SECONDARY PREVENTION OF SMALL SUBCORTICAL STROKES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。定义大脑小动脉疾病的有效治疗方法及其两个最常见的临床表现：皮质下小中风和认知能力下降。患者最佳的抗血小板治疗和抗高血压治疗可以减少中风复发和认知功能下降，目前还没有明确的定义，可能会产生重要的健康益处。虽然在没有手术治疗的颈动脉狭窄和主要危险的心脏栓塞源的情况下，MRI定义的有症状的皮质下小中风是参与研究的合格事件，复发中风是主要结果，但研究的目标范围更广，包括对血管性痴呆的评估和预防。这项研究将为没有动脉内膜切除术或抗凝指征的患者确定预防中风复发和认知能力下降的最佳治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Define the efficacious therapies for cerebral small artery disease and its two most common clinical manifestations: small subcortical strokes and cognitive decline. Optimal antiplatelet therapy and antihypertensive management of patients to reduce stroke recurrence and cognitive decline has not been defined and is likely to yield important health benefits. Although MRI-defined symptomatic small subcortical strokes in the absence of surgically amenable cervical carotid stenosis and major-risk cardioembolic sources is the qualifying event for participation in the study and recurrent stroke is the primary outcome, the goals of the study are broader in scope and include assessment and prevention of vascular dementia. This study will define optimal treatment to prevent recurrent stroke and cognitive decline for patients without an indication for endarterectomy or anticoagulation.