SECONDARY PREVENTION OF SMALL SUBCORTICAL STROKES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。定义脑小动脉疾病的有效治疗方法及其两种最常见的临床表现：皮质下小卒中和认知能力下降。最佳的抗血小板治疗和抗高血压管理的患者，以减少中风复发和认知能力下降尚未确定，可能会产生重要的健康效益。虽然MRI定义的症状性皮质下小卒中，在没有手术可行的颈动脉狭窄和主要风险心源性栓塞的情况下，是参与研究的合格事件，复发性卒中是主要结局，但研究的目标范围更广，包括评估和预防血管性痴呆。本研究将确定最佳治疗方法，以预防无动脉内膜切除术或抗凝治疗指征的患者的复发性卒中和认知能力下降。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Define the efficacious therapies for cerebral small artery disease and its two most common clinical manifestations: small subcortical strokes and cognitive decline. Optimal antiplatelet therapy and antihypertensive management of patients to reduce stroke recurrence and cognitive decline has not been defined and is likely to yield important health benefits. Although MRI-defined symptomatic small subcortical strokes in the absence of surgically amenable cervical carotid stenosis and major-risk cardioembolic sources is the qualifying event for participation in the study and recurrent stroke is the primary outcome, the goals of the study are broader in scope and include assessment and prevention of vascular dementia. This study will define optimal treatment to prevent recurrent stroke and cognitive decline for patients without an indication for endarterectomy or anticoagulation.