EFFECT OF POTASSIUM ALKALI ON BONE LOSS AND STONE RISK INDUCED BY ATKINS' DIET

碱钾对阿特金斯饮食引起的骨质流失和结石风险的影响

• 批准号: 7377639
• 负责人: KHASHAYAR SAKHAEE
• 金额: $ 11.72万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377639
• 关键词: EFFECT; POTASSIUM; ALKALI; BONE; LOSS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to continue efforts toward identifying potential deleterious effects of high animal protein diet on bone metabolism and kidney stone formation, and ascertain the value of potassium alkali as a countermeasure. The overall hypotheses to be tested are: 1) a high animal protein intake confers an acid load, which then causes bone loss and increases stone-forming risk, 2) potassium citrate corrects these deleterious effects by "neutralizing" the acid load, 3) intestinal calcium absorption is enhanced by potassium alkali in the setting of an acid load. The model for animal protein excess adopted in this effort is the Atkins' diet, where in the restriction of carbohydrates and liveral intake of fat leads to an exaggerated intake of animal proteins that confers a marked acid load.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本项目的目标是继续努力确定高动物蛋白饮食对骨代谢和肾结石形成的潜在有害影响，并确定钾碱作为对策的价值。要检验的总体假设是：1)大量摄入动物蛋白会带来酸负荷，从而导致骨质流失并增加结石形成的风险；2)柠檬酸钾通过“中和”酸负荷来纠正这些有害影响；3)在酸负荷的情况下，钾碱能促进肠道钙的吸收。在这项工作中采用的动物蛋白过量的模型是阿特金斯的饮食，在限制碳水化合物和利弗兰脂肪摄入量的情况下，会导致动物蛋白的夸大摄入，从而导致明显的酸负荷。