PHASE I/II STUDY OF XCELLERATED T CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA

慢性淋巴细胞白血病 XCELLERATED T 细胞的 I/II 期研究

• 批准号: 7374172
• 负责人: Thomas J Kipps
• 金额: $ 0.42万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374172
• 关键词: B lymphocyte; flow cytometry; immunoglobulins; lymph nodes; lymphocyte; neoplasm /cancer; phenotype

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Test the safety and determine the maximum tolerated dose of Xcellerated T Cells in patients with chronic lymphocytic leukemia. In addition, lymphocyte counts, lymph node area, and quantitative immunoglobulins will be assessed for preliminary evidence of a therapeutic effect. Changes in the phenotype of T and B lymphocytes will be evaluated by flow cytometry. Changes in T cell repertoire and anti-tumor immune activity will also be assessed.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。检测慢性淋巴细胞白血病患者使用加速T细胞的安全性并确定其最大耐受剂量。此外，将对淋巴细胞计数、淋巴结面积和定量免疫球蛋白进行评估，作为治疗效果的初步证据。T淋巴细胞和B淋巴细胞表型的变化将通过流式细胞术进行评估。还将评估T细胞库和抗肿瘤免疫活性的变化。