AASK AND HYPERTENSION COHORT STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。非裔美国人面临着遭受高血压严重后果的风险。尽管血压控制很好，尽管使用了肾脏保护性抗高血压药物，高血压相关的肾脏疾病通常会进展。非裔美国人肾脏疾病和高血压研究(AASK)是一项长期的多中心、前瞻性、随机双盲试验，旨在确定血压控制水平和特定降压方案的使用对患有高血压肾硬化症的非裔美国人肾功能不全进展的影响。AASK是此类研究中的第一个大规模研究，该研究的干预部分最近成功完成。AASK的研究表明，即使在接受最有效治疗的人群中，非裔美国人的临床终点发生率和肾脏疾病的进展也很高。因此，AASK队列研究旨在前瞻性地确定患有高血压相关肾脏疾病的非裔美国人的长期肾功能病程和肾脏疾病进展的危险因素，这些疾病提供了控制血压的最佳治疗方法。队列研究的第二个目标是确定心血管疾病的发生，并在高血压相关肾脏疾病的背景下评估其危险因素。预计AASK队列研究将提供数据，以加强对决定肾脏疾病进展的过程的理解。这项研究的成功完成可能最终导致新的预防策略，推迟终末期肾病的发生。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. African American are at risk to suffer severe consequences of hypertension. Despite excellent blood pressure control and despite use of reno-protective antihypertensive medication, hypertension-related renal disease commonly progresses. The African American Study of Kidney Disease and Hypertension (AASK) was a long-term multi-center, prospective, randomized double0blinded trial to determine the effects of blood pressure control levels and the use of specific anti-hypertensive regimens on the progression of renal insufficiency in African Americans with hypertensive nephrosclerosis. The AASK was the first large-scale study of its kind, and the intervention part of the study was recently and successfully completed. The AASK study demonstrated that the incidence of clinical endpoints and the progression of kidney disease were high in the African American subjects, even in the group that received the most effective therapy. Therefore, the AASK Cohort study is designed to determine prospectively the long-term course of kidney function and risk factors for kidney disease progression in African Americans with hypertension-related kidney disease that are provided optimal therapy to control blood pressure. A secondary objective of the Cohort study is to determine the occurance of cardiovascular disease and assess its risk factors in the setting of hypertension-related kidney disease. It is anticipated that the AASK Cohort study will provide data that enhance the understanding of the processes that determine progression of renal disease. Successful completion of this study might ultimately lead to new prevention strategies that delay the onset of end Stage renal disease.