THE BOSTON MEDICAL CENTER BOSTON OBESITY, GENETICS AND LIFESTYLE (BOGL) STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们建议成立波士顿医学中心波士顿肥胖遗传学和生活方式(BOGL)研究小组，以便从大量成年人中收集血浆样本、白细胞(DNA)和与肥胖相关的健康信息。所有目前超重或肥胖、或减轻超重或肥胖的患者，包括在波士顿医疗中心营养和体重管理中心(NWMC)寻求治疗的现有或新患者，都有资格参加这项观察性研究。目标是招收1000名男性和1000名女性。将收集有关心脏病、糖尿病和肥胖症的患者和家族史的信息。患者和医生可以决定任何减肥治疗方案。在基线评估后48周，患者将接受后续电话采访，如果在48周在诊所就诊，则接受面对面评估，以记录前48周的当前健康状况和病史。此外，我们将审查与指定的48周期间有关的医疗记录，以确定测量的体重，核实健康信息，并确定在此期间的治疗方案。受试者将继续像往常一样在西北医疗中心接受标准治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose the formation of the Boston Medical Center Boston Obesity Genetics and Lifestyle (BOGL) Study team in order to collect plasma samples, white blood cells (DNA) and obesity-related health information from a large population of adults. All presently overweight or obese, or reduced overweight or obese patients, including current or new patients seeking treatment at the Boston Medical Center Nutrition and Weight Management Center (NWMC) who are willing to participate in this observational study, are eligible. The goal is to enroll 1000 men and 1000 women. Information pertaining to patient and family history of heart disease, diabetes, and obesity will be collected. Patients and physicians may decide on any weight loss treatment options. At 48 weeks post-baseline assessment patients will receive follow-up phone interviews or, if seen in clinic at week 48, an in-person assessment, to capture current health status and history over the previous 48 weeks. In addition, we will review medical records pertaining to the specified 48 week period to ascertain measured body weight, verify health informaiton, and to determine the treatment protocols during this period. Subjects will continue to receive standard of care treatment as usual in the NWMC.