Boston University/Lata Medical Research Foundation and Indira Gandhi Government Medical Center Global Network for Women's Children's Health Research Unit

项目摘要/摘要 波士顿大学全球网络(GN)研究单位(RU)和英迪拉·甘地政府医疗 印度那格浦尔的大学(IGGMC)/拉塔医学研究基金会(LMRF)正在申请Re- NICHD全球妇女儿童健康研究网络竞赛继续其 参与GN研究任务。自从位于印度东部那格浦尔的RU 马哈拉施特拉邦的新生儿和婴儿死亡率高于印度的总体死亡率， 改善RU集水区母亲及其婴儿健康状况的重要需要。RU 具有领导和开展国际多中心协作临床试验的丰富经验 实施科学研究致力于就改善孕产妇和妇女健康的最佳方法产生证据 儿童健康在其有需要的人口中。RU的其他优势包括它能够招募10,000名员工 孕妇每年参加GN研究，保留率为99%，并指导初级调查人员。 那格浦尔盟在未来五年的目标是双重的。第一个目标是继续参与 在妇女和儿童人群中进行的多中心、高影响、成本效益高的大规模临床研究 死亡和残疾的负担是全球最高的。第二个目标是加强对青少年的指导。 研究人员提高他们的研究能力和出版记录，并支持他们的能力 成功争取到研究重要公共卫生干预措施的拨款。RU的具体目标是 为：(1)制定战略，以继续那格浦尔地区的增长和发展，并维持 支持那格浦尔学院公共卫生研究设计和实施的研究基础设施 机构；(2)加强对孕期和死亡率的主要原因的研究 GN和那格浦尔地区的幼儿；(3)向GN提供支持，以继续识别和 解决孕产妇和儿童研究方面的差距。 Nagpur RU建议通过在#年继续与GN合作来实现他们的目标和具体目的 针对知识中的关键差距进行科学合理和严格设计的共同方案， 关于在资源有限的情况下改善母亲及其婴儿的健康结果。那格浦尔RU 将继续向GN提供科学专门知识，特别是在那格浦尔的具体优势领域 RU，包括儿科、新生儿科、传染病(儿童肺炎/新生儿败血症/腹泻)， 环境暴露，特别是家庭空气污染、营养/营养不良、产科和检测 用于产科和儿科发病率和并发症的护理点诊断的新型mHealth干预措施。

Project Summary/Abstract The Global Network (GN) Research Unit (RU) of Boston University and the Indira Gandhi Government Medical College (IGGMC)/Lata Medical Research Foundation (LMRF) in Nagpur, India are applying to the re- competition of NICHD’s Global Network of Women and Children’s Health Research to continue their participation in GN research mission. Since the Nagpur-based RU in the eastern part of the Indian state of Maharashtra has neonatal and infant mortality rates that are higher than overall rates in India, there is an important need to improve health outcomes of mothers and their infants in the RU catchment area. The RU has extensive experience in leading and conducting international multicenter collaborative clinical trials and implementation science research dedicated to generating evidence on the best ways to improve maternal and child health in its population in need. Additional strengths of the RU include its ability to recruit >10,000 pregnant women/year into GN studies with > 99% retention rates, and mentoring of junior investigators. The goals of the Nagpur RU over the next five years are twofold. The first goal is to continue to participate in multicenter, high impact, cost-effective, large scale clinical studies in populations of women and children that have the highest burden of death and disability globally. The second goal is to augment the mentoring of junior researchers to improve their research capacity and publication records and to support their ability to successfully compete for grants to study important public health interventions. The specific aims of the RU are to: (1) develop strategies to continue the growth and development of the Nagpur RU and to sustain the research infrastructure that supports the design and conduct of public health research in the Nagpur academic institutions; (2) strengthen research focused on the leading causes of morbidity and mortality in pregnancy and early childhood in the GN and in the Nagpur area; (3) provide support to the GN to continue to identify and address gaps in maternal and child research. The Nagpur RU proposes to achieve their goals and specific aims by continuing to collaborate with the GN in conducting scientifically justified and rigorously designed common protocols targeting key gaps in knowledge, relating to improving health outcomes in mothers and their infants in resource-limited settings. The Nagpur RU will continue to contribute scientific expertise to the GN, particularly in areas of specific strength in the Nagpur RU, including pediatrics, neonatology, infectious diseases, (childhood pneumonia/neonatal sepsis/diarrhea), environmental exposures, particularly household air pollution, nutrition/malnutrition, obstetrics and testing of novel mHealth interventions for point-of-care diagnosis of obstetric and pediatric morbidity and complications.