TESTOSTERONE DOSE RESPONSE IN SURGICALLY MENOPAUSAL WOMEN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。正常情况下，女性即使在绝经后也会在卵巢中产生睾酮。通过手术切除两个卵巢的女性通常睾丸激素水平较低，这可能会导致性功能、肌肉功能和总体幸福感下降。这项研究的目的是确定在绝经前切除卵巢且血液中睾酮水平较低的女性的睾酮最合适的剂量。最合适的睾酮剂量应该是使有益效果最大化同时使副作用最小化的睾酮剂量。我们将随机将140名年龄在21岁至60岁之间的切除卵巢的女性分为四组，每组接受安慰剂或三剂睾酮中的一剂，为期6个月（双盲）。在研究期间，受试者还将接受雌激素贴片治疗。睾丸激素的影响将通过测量瘦身体组织、肌肉大小、肌肉力量和腿部力量、性功能和大脑功能来确定。我们还将测量血浆脂质（血液中的胆固醇）和一些胰岛素敏感性功能（身体如何处理糖）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Normally women produce testosterone in their ovaries even after menopause. Women who have had both ovaries removed by surgery usually have low testosterone levels which may contribute to reduced sexual function, muscle function and general sense of well being. The purpose of this study is to determine what the most appropriate dose of testosterone is to give to women who have had their ovaries removed before menopause and have low testosterone levels in their blood. The most appropriate dose of testosterone will be the amount of testosterone that maximizes the beneficial effects while minimizing side effects. We will do this by randomly assigning 140 women between the ages of 21 and 60 who have had their ovaries removed to four groups which receive either placebo or one of three doses of testosterone by weekly injections for 6 months (double blind.) Subjects will also be treated with an estrogen patch during the study. The effects of testosterone will be determined by measuring lean body tissue, muscle size, muscle strength and leg power, sexual function and brain function. We will also measure plasma lippids (cholesterol in the blood and some functions of insulin sensitivity (how the body handles sugar).