TESTOSTERONE DOSE RESPONSE IN SURGICALLY MENOPAUSAL WOMEN

接受手术的绝经期女性的睾酮剂量反应

• 批准号: 7606264
• 负责人: SHALENDER BHASIN
• 金额: $ 13.75万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606264
• 关键词: Adverse effects; Age; Blood; Brain; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Dose; Double-Blind Method; Estrogens; Funding; Grant; Injection of therapeutic agent; Institution; Leg; Measures; Menopause; Muscle function; Operative Surgical Procedures; Ovary; Placebos; Plasma; Purpose; Randomized; Research; Research Personnel; Resources; Sex Functioning; Source; Testosterone; Tissues; United States National Institutes of Health; Well in self; Woman; insulin sensitivity; muscle strength; response; size; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Normally women produce testosterone in their ovaries even after menopause. Women who have had both ovaries removed by surgery usually have low testosterone levels which may contribute to reduced sexual function, muscle function and general sense of well being. The purpose of this study is to determine what the most appropriate dose of testosterone is to give to women who have had their ovaries removed before menopause and have low testosterone levels in their blood. The most appropriate dose of testosterone will be the amount of testosterone that maximizes the beneficial effects while minimizing side effects. We will do this by randomly assigning 140 women between the ages of 21 and 60 who have had their ovaries removed to four groups which receive either placebo or one of three doses of testosterone by weekly injections for 6 months (double blind.) Subjects will also be treated with an estrogen patch during the study. The effects of testosterone will be determined by measuring lean body tissue, muscle size, muscle strength and leg power, sexual function and brain function. We will also measure plasma lippids (cholesterol in the blood and some functions of insulin sensitivity (how the body handles sugar).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 通常，女性即使在绝经后也会在卵巢中产生睾酮。通过手术切除双侧卵巢的女性通常睾酮水平较低，这可能会导致性功能、肌肉功能和总体幸福感下降。本研究的目的是确定对于绝经前切除卵巢且血液中睾酮水平较低的女性，最合适的睾酮剂量是多少。最合适的睾酮剂量是能够最大化有益效果同时最小化副作用的睾酮量。为此，我们将 140 名年龄在 21 岁至 60 岁之间、已切除卵巢的女性随机分配到四组，每组接受安慰剂或每周注射三剂睾酮中的一种，持续 6 个月（双盲）。研究期间，受试者还将接受雌激素贴片治疗。睾酮的作用将通过测量瘦身体组织、肌肉大小、肌肉力量和腿部力量、性功能和大脑功能来确定。我们还将测量血浆脂质（血液中的胆固醇和胰岛素敏感性的一些功能（身体如何处理糖）。