MECHANISMS OF EXERCISE INTOLERANCE AND EFFECTS OF TRAINING IN CHILDREN WITH HEAE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目将招募6至13岁的儿童，其中包括丰坦手术后的单心室儿童40名，心脏移植后的儿童40名，以及健康儿童40名作为对照。注册的儿童将被随机安排参加为期6周的运动训练计划或夏季的计算机课程。受试者将在运动训练前后对门诊GCRC进行一次全天的访问。将进行营养评估、DEXA扫描、大腿MRI、超声心动图、肺功能测试和自行车运动试验。将抽血化验儿茶酚胺和细胞因子。家长们将填写两份调查问卷。在GCRC访问后，受试者将佩戴活动监测器2周。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will recruit children 6 to 13 years of age, including 40 children with single ventricle after the Fontan operation, 40 children after heart transplant, and 40 healthy children as controls. Enrolled children will be randomized to a 6-week exercise training program or computer class in the summer. Subjects will have one full-day visit to the outpatient GCRC before and after the exercise training. Nutrition assessment, DEXA scan, MRI of thigh, echocardiogram, pulmonary function test and cycle ergometer exercise test will be performed. Blood will be drawn for catecholamine and cytokine assays. The parents will fill out two questionnaires. After GCRC visit, the subjects will wear an activity monitor for 2 weeks.