USE OF PHONOCARDIOGRAM IN SCREENING NEONATES FOR CONGENITAL HEART DISEASE

使用心音图筛查新生儿先天性心脏病

• 批准号: 8174491
• 负责人: RUEY-KANG R CHANG
• 金额: $ 1.87万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174491
• 关键词: Accounting; Birth; Cessation of life; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Congenital Abnormality; Diagnosis; Electrocardiogram; Event; Feasibility Studies; Foundations; Funding; Future; Grant; Heart Sounds; Hospitals; Infant; Institution; Life; Morbidity - disease rate; Newborn Infant; Pulse Oximetry; Research; Research Personnel; Resources; Screening procedure; Source; Techniques; Technology; Testing; United States National Institutes of Health; congenital heart disorder; disease diagnosis; neonate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Congenital heart disease (CHD) is the most common major congenital anomaly and account for the majority of death due to congenital malformation in the first year of life. Many infants born with CHD are discharged from hospital after birth without being diagnosed. Delayed diagnosis and treatment can often result in life-threatenting events and significant morbidities in these infants. Therefore, early CHD diagnosis using screening techniques may be life-saving. Previous researchers have used ECG and pulse oximetry as screening for CHD with some promises. We propose to use heart sound in addition to current technology to aid CHD screening in newborns. The achieve this, we propose the current feasibility study on newborn heart sounds to establish the foundation for our future studies on CHD screening in newborns. This study has two specific aims: Specific Aim#1 To test the feasibility of heart sound recording in newborns Specific Aim#2 To determine the heart sound characteristics and parameters in newborns

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 先天性心脏病（CHD）是最常见的主要先天性畸形，占出生后第一年内因先天性畸形而死亡的大多数。 许多先天性心脏病的婴儿在出生后未经诊断就出院了。 延误诊断和治疗往往会导致危及生命的事件和显着的发病率在这些婴儿。 因此，使用筛查技术进行早期CHD诊断可能挽救生命。 以前的研究人员使用心电图和脉搏血氧饱和度作为冠心病的筛查，有一定的前景。 我们建议在现有技术的基础上使用心音来辅助新生儿CHD筛查。 为此，我们提出了目前新生儿心音的可行性研究，为我们未来在新生儿CHD筛查方面的研究奠定基础。 这项研究有两个具体目标： 具体目标#1 探讨新生儿心音记录的可行性 具体目标#2 测定新生儿心音特征及参数