Infant Sleep Environment Monitoring System (SEMS) for SIDS

针对 SIDS 的婴儿睡眠环境监测系统 (SEMS)

• 批准号: 8395020
• 负责人: RUEY-KANG R CHANG
• 金额: $ 28.14万
• 依托单位: INTELLIGENT OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8395020
• 关键词: Acoustics; Age-Months; Algorithms; American; Apnea; Area; Asphyxia; Back to Sleep; Beds; Biomedical Research; Body Temperature; California; Carbon Dioxide; Cause of Death; Clinical Research; Clinical Trials; Clothing; Collaborations; Complex; Computers; Data; Detection; Development; Devices; Electronics; Engineering; Environment; Environmental Risk Factor; Family; Future; Goals; Head; Heat Stress Disorders; Incidence; Infant; Internet; Lead; Legal patent; Link; Literature; Los Angeles; Measures; Medical; Medical center; Monitor; Optics; Pain; Parents; Performance; Phase; Polysomnography; Prevention Research; Process; Qualifying; Reaction Time; Research; Research Institute; Research Personnel; Respiratory Sounds; Risk; Risk Factors; Scientist; Secure; Signal Transduction; Skin; Sleep; Sudden infant death syndrome; System; Telemetry; Temperature; Testing; Universities; Validation; Wireless Technology; base; clinically relevant; clinically significant; computerized data processing; design; effective intervention; environmental change; high risk infant; human subject; meetings; miniaturize; modifiable risk; notch protein; optical sensor; phase 1 study; phase 2 study; prevent; product development; research clinical testing; respiratory; sensor; sleep position; success

DESCRIPTION (provided by applicant): Many cases of Sudden Infant Death Syndrome (SIDS) could be avoided if the known sleep situations linked to SIDS could be detected and corrected way early before suffocation and/or apnea occurs. Prone sleep position and covering of the head by bedding are two most important environmental risk factors for SIDS. The infant Sleep Environment Monitoring System (SEMS) is designed to detect these conditions that lead to changes in key parameters signaling the onset of the complex pathophysiologic processes for SIDS. The SEMS is a wireless local and remote monitoring system that consists of three components: an Infant Module (IM), a Local Gateway, and a Remote Monitoring Server. The IM transmits signals wirelessly to a local gateway device by the crib, which processes the signals and sends results via the Internet to a secure remote monitoring server. The IM will be attached to the baby's clothing with a small area of skin contact at the suprasternal notch. Four sensors will be placed in the IM to monitor important sleep environmental changes which are early precursors for SIDS. The SEMS sensor package includes accelerometers for sleep position, an optical CO2 microsensor, a thermistor for temperature, and an acoustic sensor for airway flow. Sleep position - Avoiding prone sleep position is the most important way to prevent SIDS. Carbon dioxide and Temperature - In clinically significant head-covering episodes, CO2 accumulates and body temperature rises, leading to CO2 rebreathing, heat stress and ultimately respiratory suppression and apnea. Airway flow - A decreased of airway acoustic signals can be detected before suffocation and apnea occur. In the Phase I study we aim to develop and validate all 4 sensors used in the IM. The unique collaboration between Intelligent Optical Systems, the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, and the Electrical and Computer Engineering Department of the University of California Irvine formed to carry out this project is imminently qualified to take it from Phase I proof of principal through final product development and clinical testing. A patent application for this approach has been filed. PUBLIC HEALTH RELEVANCE: This project will develop an easy-to-use monitor to help prevent "crib death" (sudden infant death syndrome, or SIDS), which causes the painful loss of a baby in 2,500 American families each year. The infant Sleep Environment Monitoring System (SEMS), developed by a team of medical researchers, sensor scientists, and electronic engineers, will use a miniaturized sensor package to measure critical sleep parameters, including sleep position, carbon dioxide, temperature, and breathing sounds. The SEMS will focus on sleep position and head covering by bedding -- the two most important risk factors in an infant's sleep environment that can be recognized and corrected by parents to prevent SIDS.

描述（由申请人提供）：如果能够在窒息和/或呼吸暂停发生之前尽早检测到并纠正与 SIDS 相关的已知睡眠情况，许多婴儿猝死综合症 (SIDS) 病例就可以避免。俯卧睡姿和用被褥覆盖头部是婴儿猝死综合症 (SIDS) 的两个最重要的环境风险因素。婴儿睡眠环境监测系统 (SEMS) 旨在检测这些导致关键参数变化的情况，这些参数表明 SIDS 复杂病理生理过程的开始。 SEMS 是一个无线本地和远程监控系统，由三个组件组成：婴儿模块 (IM)、本地网关和远程监控服务器。 IM 通过婴儿床将信号无线传输到本地网关设备，本地网关设备处​​理信号并通过互联网将结果发送到安全的远程监控服务器。 IM 将附着在婴儿的衣服上，并在胸骨上切迹处有一小部分皮肤接触。 IM 中将放置四个传感器来监测重要的睡眠环境变化，这些变化是 SIDS 的早期先兆。 SEMS 传感器套件包括用于睡眠位置的加速度计、光学 CO2 微传感器、用于温度的热敏电阻以及用于气道流量的声学传感器。睡眠姿势 - 避免俯卧睡眠姿势是预防 SIDS 的最重要方法。二氧化碳和温度 - 在具有临床意义的头部遮盖事件中，二氧化碳积聚和体温升高，导致二氧化碳再呼吸、热应激并最终导致呼吸抑制和呼吸暂停。气道流量 - 在窒息和呼吸暂停发生之前可以检测到气道声音信号的减少。在第一阶段研究中，我们的目标是开发和验证 IM 中使用的所有 4 个传感器。智能光学系统公司、哈伯-加州大学洛杉矶分校医学中心洛杉矶生物医学研究所以及加州大学欧文分校电气与计算机工程系之间的独特合作，旨在开展该项目，即将获得第一阶段主体证明的资格 通过最终产品开发和临床测试。这种方法的专利申请已经提交。 公共健康相关性：该项目将开发一种易于使用的监测器，以帮助预防“婴儿床死亡”（婴儿猝死综合症，简称 SIDS），这种现象每年导致 2,500 个美国家庭痛苦地失去婴儿。由医学研究人员、传感器科学家和电子工程师组成的团队开发的婴儿睡眠环境监测系统（SEMS）将使用微型传感器包来测量关键的睡眠参数，包括睡眠位置、二氧化碳、温度和呼吸声。 SEMS 将重点关注睡眠姿势和床上用品覆盖头部——这是婴儿睡眠环境中两个最重要的危险因素，父母可以识别和纠正这些因素，以预防 SIDS。