NBP

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。近年来，人们对与创伤后应激障碍（PTSD）相关的医学发病率非常感兴趣。心血管反应是生理反应性的一个突出特征，是该疾病的核心特征，这增加了对心血管功能持久影响的可能性。关于创伤后应激障碍是否与高血压和相关心血管疾病的风险增加有关，研究结果不一。本研究旨在探讨创伤后应激障碍与心血管调节之间的潜在联系机制，特别是夜间血压调节的作用，以及创伤暴露与夜间血压关系的假设调节因素，包括特质性愤怒、暴露于预果汁和歧视的作用。在研究的后续阶段，我们还将评估与肾上腺素能受体遗传多态性的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There has been much recent interest in medical morbidity associated with posttramatic stress disorder(PTSD). Cardiovascular response being a prominent feature of the phyciological reactivity that is a core feature of the disorder raises the possibility of enduring effects on cardiovascular function. Studies are mixed as to whether PTsd is associated with an increased risk of hypertension and related cardiovascular morbidity. The proposed study aims investigate candidate mechanisms for linking PTSD to cardiovascular regulation and, in particular, the role of nocturnal blood pressure regulation along with hypothesized modifiers of the relationship of trauma exposure and nocturnal blood pressure including the role of trait anger and exposure to prejuice and discrimination. In a subsequent phase of the research we will also evalute relationships to genetic polymorphisms of adrenergic receptors.