VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
人类的前庭交感反射
基本信息
- 批准号:7378441
- 负责人:
- 金额:$ 0.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-04-01 至 2007-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific goals of this study are to further our understanding of how activation of the vestibular system participates in orthostasis by its regulation of sympathetic nerve activity and peripheral vascular resistance in humans. We will investigate muscle sympathetic nerve activity (MSNA) and blood pressure responses: 1) during dynamic engagement of the otolith organs, 2) during engagement of the otolith organs in the upright posture, and 3) during engagement of the vestibulosympathetic reflex in subjects predisposed to orthostatic intolerance. Pilot data suggests that dynamic stimulation of the otolith organs elicits greater increases in MSNA during dynamic rather than static engagement of the otolith organs. This finding would support the hypothesis that the vestibulosympathetic reflex, mediated by dynamic stimulation of the otolith organs, contributes to orthostatic tolerance with changes in posture. Preliminary data also suggests that increases in MSNA by the vestibulosympathetic reflex via head-down rotation (HDR) is independent of body posture. This finding would provide the first evidence that vestibular activation in the upright posture contributes to sympathetic outflow and will support the concept that the vestibular system contributes to orthostasis in humans. Finally, pilot data suggests that vestibular activation of MSNA is attenuated in conditions that are associated with orthostatic intolerance (i.e., idiopathic orthostatic hypotension, vestibular deficient subjects, and highly trained endurance athletes), and that, blood pressure is reduced during vestibular activation in these subjects.
本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者(PI)可能已经从另一个NIH来源获得了主要资金,因此可以在其他CRISP条目中表示。列出的机构是中心的,不一定是研究者的机构。本研究的具体目标是进一步了解前庭系统的激活如何通过调节人类交感神经活动和周围血管阻力参与直立。我们将研究肌肉交感神经活动(MSNA)和血压反应:1)在动态接触耳石器官时,2)在直立姿势接触耳石器官时,3)在前庭交感反射参与时,易患直立性不耐受的受试者。试验数据表明,动态刺激耳石器官会引起动态而不是静态耳石器官的更大的MSNA增加。这一发现将支持前庭交感反射的假设,由耳石器官的动态刺激介导,有助于直立耐受与姿势的变化。初步数据还表明,前庭交感反射通过头向下旋转(HDR)增加的MSNA与身体姿势无关。这一发现将提供第一个证据,证明在直立姿势时前庭神经的激活有助于交感神经的流出,并将支持前庭神经系统有助于人类直立的概念。最后,试点数据表明,在与直立性不耐受相关的情况下(即特发性直立性低血压、前庭功能缺陷受试者和训练有素的耐力运动员),前庭功能激活会减弱,并且在这些受试者中,前庭功能激活会降低血压。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHESTER A RAY其他文献
CHESTER A RAY的其他文献
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{{ truncateString('CHESTER A RAY', 18)}}的其他基金
RESPONSES OF THE VESTIBULOSYMPATHETIC REFLEX IN ENDURANCE TRAINED SUBJECTS
耐力训练对象前庭交感反射的反应
- 批准号:
7951240 - 财政年份:2009
- 资助金额:
$ 0.3万 - 项目类别:
THE EFFECTS OF MELATONIN ON THE VESTIBULOSYMPATHETIC REFLEX
褪黑素对前庭交感神经反射的影响
- 批准号:
7951312 - 财政年份:2009
- 资助金额:
$ 0.3万 - 项目类别:
COMPARE STRAIN GAUGE PLETHYSMOGRAPHY & DOPPLER ULTRASOUND IN OBESE & TRAINED
比较应变计体积描记法
- 批准号:
7951285 - 财政年份:2009
- 资助金额:
$ 0.3万 - 项目类别:
RESPONSES OF THE VESTIBULOSYMPATHETIC REFLEX IN ENDURANCE TRAINED SUBJECTS
耐力训练对象前庭交感反射的反应
- 批准号:
7625758 - 财政年份:2007
- 资助金额:
$ 0.3万 - 项目类别:
EFFECTS OF BED REST ON THE VESTIBULOSYMPATHETIC REFLEX
卧床休息对前庭交感反射的影响
- 批准号:
7625730 - 财政年份:2007
- 资助金额:
$ 0.3万 - 项目类别:
THE EFFECT OF DEHYDRATION ON THE VESTIBULOSYMPATHETIC REFLEX
脱水对前庭交感反射的影响
- 批准号:
7625805 - 财政年份:2007
- 资助金额:
$ 0.3万 - 项目类别:
RESPONSES OF THE VESTIBULOSYMPATHETIC REFLEX IN ENDURANCE TRAINED SUBJECTS
耐力训练对象前庭交感反射的反应
- 批准号:
7378491 - 财政年份:2006
- 资助金额:
$ 0.3万 - 项目类别: