VESTIBULOSYMPATHETIC REFLEXES IN HUMANS

人类的前庭交感反射

• 批准号: 7625728
• 负责人: CHESTER A RAY
• 金额: $ 0.18万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625728
• 关键词: Attenuated; Blood Pressure; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Funding; Goals; Grant; Head; Human; Institution; Mediating; Muscle; Nerve; Organ; Orthostasis; Orthostatic Hypotension; Peripheral; Posture; Reflex action; Regulation; Research; Research Personnel; Resources; Rotation; Source; System; Training; United States National Institutes of Health; Vascular resistance; concept; otoconia; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific goals of this study are to further our understanding of how activation of the vestibular system participates in orthostasis by its regulation of sympathetic nerve activity and peripheral vascular resistance in humans. We will investigate muscle sympathetic nerve activity (MSNA) and blood pressure responses: 1) during dynamic engagement of the otolith organs, 2) during engagement of the otolith organs in the upright posture, and 3) during engagement of the vestibulosympathetic reflex in subjects predisposed to orthostatic intolerance. Pilot data suggests that dynamic stimulation of the otolith organs elicits greater increases in MSNA during dynamic rather than static engagement of the otolith organs. This finding would support the hypothesis that the vestibulosympathetic reflex, mediated by dynamic stimulation of the otolith organs, contributes to orthostatic tolerance with changes in posture. Preliminary data also suggests that increases in MSNA by the vestibulosympathetic reflex via head-down rotation (HDR) is independent of body posture. This finding would provide the first evidence that vestibular activation in the upright posture contributes to sympathetic outflow and will support the concept that the vestibular system contributes to orthostasis in humans. Finally, pilot data suggests that vestibular activation of MSNA is attenuated in conditions that are associated with orthostatic intolerance (i.e., idiopathic orthostatic hypotension, vestibular deficient subjects, and highly trained endurance athletes), and that, blood pressure is reduced during vestibular activation in these subjects.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究的具体目标是进一步了解前庭系统的激活如何通过调节人类交感神经活动和外周血管阻力来参与体位保持。我们将研究肌肉交感神经活动 (MSNA) 和血压反应：1) 耳石器官动态接合期间，2) 耳石器官处于直立姿势接合期间，3) 易患直立不耐受的受试者的前庭交感神经反射接合期间。试验数据表明，耳石器官的动态刺激在耳石器官的动态而非静态接合期间引起 MSNA 更大的增加。这一发现支持这样的假设：由耳石器官的动态刺激介导的前庭交感反射有助于姿势变化的直立耐受性。初步数据还表明，前庭交感神经反射通过低头旋转 (HDR) 增加的 MSNA 与身体姿势无关。这一发现将提供第一个证据，证明直立姿势下的前庭激活有助于交感神经流出，并将支持前庭系统有助于人类直立状态的概念。最后，试验数据表明，在与直立性不耐受相关的情况下（即特发性直立性低血压、前庭缺陷受试者和训练有素的耐力运动员），MSNA 的前庭激活会减弱，并且这些受试者的前庭激活期间血压会降低。