ROLE OF PROSTAGLANDINS IN AUTONOMIC/CARDIOVASCULAR CONTROL IN HUMANS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在这个项目中，研究人员计划确定内源性前列腺素在静止状态和生理应激时对自主神经和心血管调节的作用。此外，他们还将研究这些影响是否会随着年龄的增长而改变。研究者假设前列腺素强直性地增强压力反射敏感性，抑制交感神经流出，并以年龄依赖的方式改变骨骼肌血流对生理应激源的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, the investigators plan to determine the role of endogenous prostaglandins on autonomic and cardiovascular regulation both at rest and in response to physiological stressors. In addition, they will study if these effects are altered with age. The investigators hypothesize that prostaglandins tonically augment baroreflex sensitivity, inhibit sympathetic outflow and alter the skeletal muscle blood flow responses to physiological stressors in an age-dependent manner.