GENERAL CLINICAL RESEARCH CENTER

超出所提供的空间。 Harbor-UCLA医学中心的综合临床研究中心（GCRC）现在已经运营了31年。 该提案要求继续支助五年（2001年1月12日至2006年30月22日）的住院部（1 000天）、门诊部 设施（5，500次访问），位于Harbor-UCLA的围产期临床研究中心（PCRC）和位于 金德鲁医疗中心雪松的GCRC卫星正在增长，研究数量增加了64% 包括围产期研究以及基因分型（630，833种基因型）和细胞系的新活动的协议 在基因分型-表型核心中的开发（2，614个细胞系）。当前的应用程序包含100个协议， Harbor-UCLA和来自Cedars-Sinai医学中心的72个方案。过去五年， 港口和雪松的GCRC之间的合作，例如， 合作研究者和共享协议（16个协议）。这一合作活动的大部分都包含在 围产期研究以及基因分型和细胞系的发展，在最近资助的基因分型表型核心， 雪松-西奈这两个机构的GCRC是指导临床研究的临床研究培训的重点。 通过卫生部资助的和其他外展计划，在初级教师一级向高中学生提供研究实习生。 我们的研究重点是雄激素治疗和男性避孕药的开发;药物遗传学和 种族的心理生物学;真菌病感染的机制;老年男性和男性的运动训练和虚弱 慢性疾病;母体胎儿的新陈代谢调节，以及包括高血压和慢性 炎症性肠病我们继续支持大量的门诊研究，（例如，妇女健康倡议， 糖尿病基因的鉴定），高强度住院研究（例如，代谢和多重采样研究），围产期 研究和常见疾病的遗传学（糖尿病、动脉粥样硬化、高血压、骨质疏松症）。要适应 我们的研究人员和不断变化的临床研究重点，我们建议：1）进一步扩大我们的门诊研究 能力（海港新的门诊设施，增加两个中心的门诊就诊人数）; 2）增加数据和安全性 监察顾问/监察员，以保障研究受试者的安全; 3）鼓励 通过在Cedars建立PCRC，建立三个中心;以及4）通过以下方式增加细胞系和基因型/表型核心的使用： 两个中心。

EXCEED THE SPACE PROVIDED. The General Clinical Research Center (GCRC) at Harbor-UCLA Medical Center is now in its 31st year of operation. This proposal requests continued support for five years (12/1/01 to 22/30/06) for an inpatient unit (1000 days), outpatient facilities (5,500 visits), a Perinatal Clinical Research Center (PCRC) at Harbor-UCLA and a satellite PCRC at King-Drew Medical Center. The GCRC satellite at Cedars is growing with a 64% increase in number of research protocols with new activities encompassing perinatal research as well as genotyping (630,833 genotypes) and cell line development (2,614 cell lines) in the Genotyping-Phenotyping Core. The current applicationcontains 100 protocols from Harbor-UCLA and 72 protocols from Cedars-Sinai Medical Center. The past five years have witnessed an increased collaboration between the GCRCs at Harbor and Cedars as exemplified by a twofold increase in the number of collaborating investigators and shared protocols (16 protocols). Much of this collaborative activity is encompassed in perinatal research as well as genotyping and cell line development in the recently funded genotyping-phenotyping core at Cedars-Sinai. The GCRCs at both institutions are the focus of clinical research training from the mentored clinical research trainee at the junior faculty level to high school students through MH funded and other outreach programs. Our research focus has been on androgen therapy and male contraceptive development; pharmacogenetics and psychobiology of ethnicity; mechanisms of infection by mycoses; exercise trainingand frailty in older men and men with chronic diseases; maternal fetal osmoregulation, and the genetic basis of diseases including hypertension and chronic inflammatory bowel disease. We continue to support high volume outpatient studies,( e.g., Women's Health Initiative, identification of diabetic genes), high intensity inpatient studies (e.g., metabolic and multiple sampling studies), perinatal research, and genetics of common diseases (diabetes, atherosclerosis, hypertension, osteoporosis). To meet the needs of our investigators and the changing clinical research focus, we propose: 1) to further expand our outpatient research capability (new outpatient facilities at Harbor, increased outpatients visits at both centers); 2) to add data and safety monitoring advisors/monitors to safeguard the safety of research subjects; 3) to encourage collaboration between the three centers by establishing a PCRC at Cedars; and 4) to increase use of the cell-line and genotype/phenotype core by both centers.