General Clinical Research Center

全科临床研究中心

• 批准号: 7994747
• 负责人: Gail V Anderson
• 金额: --
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-07 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7994747
• 关键词: General; Clinical; Research; Center

The GCRC at Harbor-UCLA Medical Center and the satellite GCRC at Cedars-Sinai Medical Center are applying for continued funding of the GCRCs for 5 years (12/01/2006 to 11/30/2011). The Harbor-UCLA GCRC is requesting support for an inpatient unit (800 days), outpatient facilities (9,000 visits), a perinatal/ pediatrics unit (7,000 hrs). The Cedars GCRC satellite is seeking continued support for an outpatient unit, a complex genotype-phenotype core and a perinatal unit working closely with its Harbor counterpart. The current application contains 93 protocols from Harbor and 95 from Cedars, each with Data Safety Monitoring plans. The GCRCs are requesting support for a new joint Clinical Transcriptional Genomics, Proteomics and Molecular Cytology core with 47 protocols utilizing this proposed core. Reviewed and given an excellent score, this core was not funded in 2004 because of NCRR's budgetary constraints. Similar to the GCRC parent grant, the core's strengths include outstanding qualifications of the investigators-core directors, the capability to provide a training environment, and a substantial number of investigators and protocols from a broad range of disciplines. Our institutions have generously provided major equipment in the past 2 years and provided interim support for personnel to run the proposed core. Our presented proto-cols demonstrate the broad base of our well-funded investigators with diverse research including emerging infections, chronic kidney disease, fibroblasts in autoimmunity, male reproduction, neurotrauma, skeletal dysplasia and inflammatory bowel disease. We support high-volume outpatient studies (SELECT, Nutrition and Kidney Disease), high-intensity inpatient studies (Phase I safety and pharmacokinetics studies, metabolic and multiple sample studies), perinatal research (reproductive toxicology, methamphetamine exposed babies), behavior studies (depression, alcohol dependence), and genetics of common diseases (diabetes, diabetic nephropathy, osteoporosis, atherosclerosis). The GCRCs are the focus of clinical research training in their respective institutions reaching out to junior faculty, fellows, and minority graduate and undergraduate students, and our training activity is ranked "outstanding" in our last review. The GCRCs are positioned to be part of Centers for Clinical and Translational Sciences in our institutions following the NIH Roadmap to reengineer the clinical research enterprise of academic health centers in the nation.

Harbor-UCLA医学中心的GCRC和Cedars-Sinai医学中心的卫星GCRC正在申请GCRC的持续资助5年（2006年1月12日至2011年11月30日）。Harbor-UCLA GCRC正在请求支持住院部（800天）、门诊设施（9，000次访问）和围产期/儿科部（7，000小时）。雪松GCRC卫星正在寻求继续支持门诊单位，一个复杂的基因型-表型核心和围产期单位密切合作，其港口同行。当前的应用程序包含Harbor的93个协议和Cedars的95个协议，每个协议都带有数据安全监控计划。GCRC正在请求支持一个新的联合临床转录基因组学，蛋白质组学和分子细胞学核心，其中有47个协议使用该拟议核心。由于国家难民和康复委员会的预算限制，这一核心项目在2004年没有得到资金。与GCRC母基金类似，核心基金的优势包括核心主任的杰出资格，提供培训环境的能力，以及来自广泛学科的大量调查员和协议。我们的机构在过去两年中慷慨地提供了主要设备，并为管理拟议核心的人员提供了临时支助。我们提出的原型展示了我们资金充足的研究人员的广泛基础，包括新兴感染，慢性肾脏疾病，自身免疫中的成纤维细胞，男性生殖，神经创伤，骨骼发育不良和炎症性肠病。我们支持大量门诊研究（SELECT，营养和肾脏疾病），高强度住院研究（I期安全性和药代动力学研究，代谢和多样本研究），围产期研究（生殖毒理学，甲基苯丙胺暴露婴儿），行为研究（抑郁症，酒精依赖）和常见疾病的遗传学（糖尿病，糖尿病肾病，骨质疏松症，动脉粥样硬化）。GCRC是各自机构临床研究培训的重点，面向初级教师，研究员，少数民族研究生和本科生，我们的培训活动在上次审查中被评为“优秀”。GCRC被定位为我们机构临床和转化科学中心的一部分，遵循NIH路线图，重新设计全国学术健康中心的临床研究企业。

项目成果

Effects of sildenafil and/or muscle derived stem cells on myocardial infarction.

• DOI: 10.1186/1479-5876-10-159
• 发表时间: 2012-08-07
• 期刊: Journal of translational medicine
• 影响因子: 7.4
• 作者: Wang JS;Kovanecz I;Vernet D;Nolazco G;Kopchok GE;Chow SL;White RA;Gonzalez-Cadavid NF
• 通讯作者: Gonzalez-Cadavid NF

Prenatal methamphetamine exposure and short-term maternal and infant medical outcomes.

• DOI: 10.1055/s-0032-1304818
• 发表时间: 2012-05
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Shah R;Diaz SD;Arria A;LaGasse LL;Derauf C;Newman E;Smith LM;Huestis MA;Haning W;Strauss A;Della Grotta S;Dansereau LM;Roberts MB;Neal C;Lester BM
• 通讯作者: Lester BM

Male hormonal contraception.

• DOI: 10.1001/virtualmentor.2012.14.2.stas1-1202
• 发表时间: 2012-02-01
• 期刊: The virtual mentor : VM
• 作者: Roth, Mara Y

Relative contributions of inflammation and inadequate protein intake to hypoalbuminemia in patients on maintenance hemodialysis.

• DOI: 10.1007/s11255-012-0170-8
• 发表时间: 2013-02
• 期刊: INTERNATIONAL UROLOGY AND NEPHROLOGY
• 影响因子: 2
• 作者: Kim, Youngmee;Molnar, Miklos Z.;Rattanasompattikul, Manoch;Hatamizadeh, Parta;Benner, Debbie;Kopple, Joel D.;Kovesdy, Csaba P.;Kalantar-Zadeh, Kamyar
• 通讯作者: Kalantar-Zadeh, Kamyar

Correlates of low hemoglobin A1c in maintenance hemodialysis patients.

• DOI: 10.1007/s11255-012-0208-y
• 发表时间: 2013-08
• 期刊: INTERNATIONAL UROLOGY AND NEPHROLOGY
• 影响因子: 2
• 作者: Kim, Youngmee;Park, Jong Chan;Molnar, Miklos Z.;Shah, Anuja;Benner, Debbie;Kovesdy, Csaba P.;Kopple, Joel D.;Kalantar-Zadeh, Kamyar
• 通讯作者: Kalantar-Zadeh, Kamyar