General Clinical Research Center

全科临床研究中心

• 批准号: 7769926
• 负责人: Gail V Anderson
• 金额: $ 761.29万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-07 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7769926
• 关键词: General; Clinical; Research; Center

The GCRC at Harbor-UCLA Medical Center and the satellite GCRC at Cedars-Sinai Medical Center are applying for continued funding of the GCRCs for 5 years (12/01/2006 to 11/30/2011). The Harbor-UCLA GCRC is requesting support for an inpatient unit (800 days), outpatient facilities (9,000 visits), a perinatal/ pediatrics unit (7,000 hrs). The Cedars GCRC satellite is seeking continued support for an outpatient unit, a complex genotype-phenotype core and a perinatal unit working closely with its Harbor counterpart. The current application contains 93 protocols from Harbor and 95 from Cedars, each with Data Safety Monitoring plans. The GCRCs are requesting support for a new joint Clinjcal Transcriptional Genomics, Proteomics and Molecular Cytology core with 47 protocols utilizing this proposed core. Reviewed and given an excellent score, this core was not funded in 2004 because of NCRR's budgetary constraints. Similar to the GCRC parent grant, the core's strengths include outstanding qualifications of the investigators-core directors, the capability to provide a training environment, and a substantial number of investigators and protocols from a broad range of disciplines. Our institutions have generously provided major equipment in the past 2 years and provided interim support for personnel to run the proposed core. Our presented proto-cols demonstrate the broad base of our well-funded investigators with diverse research including emerging infections, chronic kidney disease, fibroblasts in autoimmunity, male reproduction, neurotrauma, skeletal dysplasia and inflammatory bowel disease. We support high-volume outpatient studies (SELECT, Nutrition and Kidney Disease), high-intensity inpatient studies (Phase I safety and pharmacokihetics studies, metabolic and multiple sample studies), perinatal research (reproductive toxicology, methamphetamine exposed babies), behavior studies (depression, alcohol dependence), and genetics of common diseases (diabetes, diabetic nephropathy, osteoporosis, atherosclerosis). The GCRCs are the focus of clinical research training in their respective institutions reaching out to junior faculty, fellows, and minority graduate and undergraduate students, and our training activity is ranked "outstanding" in our last review. The GCRCs are positioned to be part of Centers for Clinical and Translational Sciences in our institutions following the NIH Roadmap to reengineer the clinical research enterprise of academic health centers in the nation.

位于Harbor-UCLA医疗中心的GCRC和位于Cedars-Sinai医疗中心的卫星GCRC 申请继续资助GCRC五年（12/01/2006至11/30/2011）。加州大学洛杉矶分校 儿童权利中心请求支助一个住院部（800天）、门诊设施（9 000次就诊）、一个围产期/产期护理中心（10 000天）和一个儿童保健中心（10 000天）。 儿科股（7 000小时）。雪松GCRC卫星正在寻求继续支持门诊单位， 复杂的基因型-表型核心和围产期单位密切合作，其港口对应。的 当前的应用程序包含来自Harbor的93个协议和来自Cedars的95个协议，每个协议都具有数据安全监控功能 布局GCRC正在请求对新的联合ClinjCal转录基因组学、蛋白质组学的支持 和分子细胞学核心与47个协议利用这个建议的核心。审查并给出了一个很好的 由于国家难民救济委员会的预算限制，2004年没有为这一核心项目提供资金。类似于GCRC 母公司补助金，核心的优势包括优秀的资格认证人员-核心董事， 有能力提供培训环境，并有大量调查人员和来自 广泛的学科。我们的机构在过去两年里慷慨地提供了主要设备 并为管理拟议核心的人员提供临时支助。我们提出的协议表明 我们资金充足的调查人员的广泛基础，他们进行了各种研究，包括新出现的感染、慢性 肾脏疾病、自身免疫中的成纤维细胞、男性生殖、神经创伤、骨骼发育不良和 炎症性肠病我们支持大量门诊研究（SELECT、营养和肾脏 疾病）、高强度住院研究（I期安全性和代谢动力学研究、代谢和 多样本研究），围产期研究（生殖毒理学，接触甲基苯丙胺的婴儿）， 行为研究（抑郁症，酒精依赖）和常见疾病的遗传学（糖尿病，糖尿病 肾病、骨质疏松症、动脉粥样硬化）。GCRC是临床研究培训的重点， 各机构向初级教师、研究员和少数民族研究生和本科生伸出援手 我们的培训活动在上次评审中被评为“优秀”。GCRC的定位是 我们机构的临床和转化科学中心的一部分，遵循NIH路线图， 全国学术健康中心的临床研究企业。