ADPKD COHORT STUDY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study proposes to: characterize ADPKD patients at greatest risk for progression to end stage renal disease (ESRD) in a prospective fashion; determine if magnetic resonance imaging (MRI) as opposed to ultrasound is more reliable and accurate in measuring renal volume and the change in renal volume over time in ADPKD patients; determine if progression of renal disease in high risk ADPKD subjects followed early in the course of their disease is better detected by change in renal volume as opposed to change in glomerular filtration rate; and, determine if specific mutations in the PKD1 or PKD2 gene are associated with more aggressive phenotype.