Whole-Room Calorimeter

全房间热量计

• 批准号: 10431445
• 负责人: ARLENE B CHAPMAN
• 金额: $ 128.4万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10431445
• 关键词: Advocate; Anorexia; Body Weight decreased; Chicago; Chronic Kidney Failure; Cities; Complex; Congestive Heart Failure; Controlled Environment; Diabetes Mellitus; Disease; Eating; Energy Metabolism; Equipment; Family; Food; Funding; Gold; Head; Health; Hospitals; Hour; Illinois; Inflammatory Bowel Diseases; Institutes; Institution; Investigation; Kidney Diseases; Life; Long COVID; Measurement; Measures; Medical; Metabolic; Metabolic syndrome; Metabolism; Michigan; Obesity; Patients; Physical activity; Research; Research Personnel; Rest; Role; Site; Sleep; Technology; Thyroid Diseases; Thyroid Function Tests; United States National Institutes of Health; Universities; Wisconsin; base; circadian; circadian biology; doubly-labeled water; experience; frailty; instrumentation; microbiome; nutrition; programs; standard measure; translational medicine

Abstract The Institute for Translational Medicine (ITM) at the University of Chicago (UChicago) proposes to purchase and install a large and flex indirect calorimeter (IC) to support leading research programs in metabolism, diabetes, obesity, disorders of thyroid function, the microbiome, inflammatory bowel disease, weight reduction, frailty, circadian biology, and kidney disorders, among others. IC is the gold standard for measuring energy expenditure (EE) providing precise and accurate measures under regulated environmental conditions, ranging from maximal physical activity to sleep (SMR). For over 15 years UChicago investigators have measured EE using metabolic carts and doubly-labelled water, which only measures resting EE or RMR, for a limited duration (maximum 4 hours), requiring an over-the-head hood placement, limiting free mobility and with less precision than IC. Despite these limitations, UChicago NIH-funded investigators have incorporated measures of EE since 2004 resulting in highly impactful scientific findings. The IC proposed in this application is the only equipment available for long term (24hrs or more) EE measurements, that can determine circadian EE (ie RMR vs. SMR) with strictly controlled environmental conditions while aspects of daily life are evaluated including eating or thermal effects of food (TEF), sleeping (SMR) and physical activity. With the establishment of the Microbiome Center in 2015 and the Duchossois Family Institute in 2017 at UChicago, world-leading programs in the microbiome in health and disease are now being established. There is strong evidence for the impact of the microbiome on EE in a variety of complex medical disorders such as obesity, anorexia, metabolic syndrome, diabetes, circadian biology, chronic kidney disease, post COVID 19 syndromes, congestive heart failure and inflammatory bowel disease. However, EE changes associated with these disorders are nuanced and limitations in precision and accuracy require better instrumentation. Use of the IC proposed in this application will help to optimize patient long-term health in a variety of medical settings. By having capacity for IC measurement of EE while collecting biofluids simultaneously in a controlled environment, the contributory roles of the microbiome, metabolism and circadian biology can be characterized. Through the ITM, a multi-institution CTSA program partnered with Rush University and affiliated with Loyola University, Northshore Hospital, Advocate Center and the Illinois Institute for Technology, city-wide utilization of the IC will be facilitated and supported. Investigators from other Chicago- based institutions including Northwestern University and University of Illinois, and regional or great lakes such as University of Wisconsin and the Nutrition Obesity Research Center (NORC) investigators from University of Michigan, will perform scientific investigations. Seminars with experienced investigators in EE from other sites will advance and disseminate scientific findings from this center and advance multiple fields forward.

抽象的 芝加哥大学 (UChicago) 转化医学研究所 (ITM) 提议购买和 安装大型灵活的间接热量计 (IC)，以支持新陈代谢、糖尿病、 肥胖、甲状腺功能紊乱、微生物群、炎症性肠病、体重减轻、虚弱、 昼夜节律生物学和肾脏疾病等。 IC 是测量能量消耗的黄金标准 (EE) 在规定的环境条件下提供精确和准确的测量，范围从最大 身体活动到睡眠（SMR）。 15 年来，芝加哥大学研究人员一直使用代谢测量 EE 手推车和双标签水，仅在有限的时间内测量静息 EE 或 RMR（最多 4 小时），需要将头罩放置在头顶上，限制了自由活动并且精度低于 IC。尽管 鉴于这些限制，芝加哥大学 NIH 资助的研究人员自 2004 年起就纳入了 EE 措施，结果 极具影响力的科学发现。本申请中提出的 IC 是唯一可长期使用的设备 术语（24小时或更长）EE测量，可以严格确定昼夜EE（即RMR与SMR） 控制环境条件，同时评估日常生活的各个方面，包括饮食或热效应 食物 (TEF)、睡眠 (SMR) 和体力活动。 2015年微生物组中心成立 和 2017 年芝加哥大学杜乔索瓦家庭研究所 (Duchossois Family Institute) 开展的健康微生物组世界领先项目 现在正在确定疾病。有强有力的证据表明微生物组对 EE 的影响 各种复杂的医学疾病，如肥胖、厌食症、代谢综合征、糖尿病、昼夜节律生物学、 慢性肾病、COVID-19 后综合症、充血性心力衰竭和炎症性肠病。 然而，与这些疾病相关的 EE 变化是微妙的，并且精确度和准确性受到限制 需要更好的仪器。使用本申请中提出的 IC 将有助于优化患者的长期治疗 各种医疗环境中的健康。通过在收集生物体液时具有 IC 测量 EE 的能力 同时在受控环境中，微生物组、新陈代谢和昼夜节律的贡献作用 可以表征生物学。通过 ITM，与拉什大学合作的多机构 CTSA 计划 隶属于洛约拉大学、北岸医院、倡导中心和伊利诺伊州研究所 将促进和支持IC在全市范围内的技术应用。来自芝加哥其他地区的调查员—— 包括西北大学和伊利诺伊大学在内的机构，以及区域或五大湖，例如 威斯康星大学和营养肥胖研究中心 (NORC) 的研究人员 密歇根州将进行科学研究。与来自其他站点的 EE 领域经验丰富的研究人员一起举办研讨会 将推进和传播该中心的科学发现，并推动多个领域的发展。