THE ADPKD COHORT STUDY

ADPKD 队列研究

• 批准号: 7603645
• 负责人: ARLENE B CHAPMAN
• 金额: $ 0.13万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603645
• 关键词: Autosomal Dominant Polycystic Kidney; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Disease; End stage renal failure; Funding; Glomerular Filtration Rate; Grant; Institution; Kidney; Kidney Diseases; Magnetic Resonance Imaging; Measures; Mutation; PKD2 gene; Patients; Phenotype; Research; Research Personnel; Resources; Risk; Source; Time; Ultrasonography; United States National Institutes of Health; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study proposes to: characterize ADPKD patients at greatest risk for progression to end stage renal disease (ESRD) in a prospective fashion; determine if magnetic resonance imaging (MRI) as opposed to ultrasound is more reliable and accurate in measuring renal volume and the change in renal volume over time in ADPKD patients; determine if progression of renal disease in high risk ADPKD subjects followed early in the course of their disease is better detected by change in renal volume as opposed to change in glomerular filtration rate; and, determine if specific mutations in the PKD1 or PKD2 gene are associated with more aggressive phenotype.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究建议：以前瞻性方式表征进展为终末期肾病（ESRD）风险最大的ADPKD患者;确定磁共振成像（MRI）与超声相比，在测量ADPKD患者的肾脏体积和肾脏体积随时间的变化方面是否更可靠和准确;确定在病程早期随访的高风险ADPKD受试者的肾脏疾病进展是否可以通过肾脏体积的变化更好地检测，而不是肾小球滤过率的改变;确定PKD 1或PKD 2基因的特定突变是否与更具侵袭性的表型相关。