SYMPATHETIC CONTROL OF VASCULAR TONE IN OBESITY: INTERACTION WITH HYPERTENSION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。交感神经系统在肥胖中的作用存在争议。许多动物研究报告称，交感神经活动减少。然而，在人类肥胖中已经显示出交感神经的激活。对去甲肾上腺素的升压反应增强也有报道。在肥胖症和肥胖相关高血压中，交感神经系统对基础血管张力的作用知之甚少。因此，这些研究人员的目标是验证这一假说，即肥胖患者的血管张力是通过交感神经作用机制增加的。体重减轻与动脉压降低有关。他们还假设，体重减轻会导致交感神经调节的血管张力降低，从而降低动脉压。本研究将为肥胖及肥胖相关高血压患者交感神经系统对血管张力的调控提供有价值的信息。此外，这一结果可能会为预防肥胖引起的心血管并发症提供新的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The role of the sympathetic nervous system in obesity is controversial. Many studies in animals report decreased sympathetic nervous activity. However, sympathoactivation has been shown in human obesity. Enhanced pressor response to norepinephrine has also been reported. Little is known about the contribution of the sympathetic nervous system to basal vascular tone in obesity and in obesity-related hypertension. These investigators aim, therefore, to test the hypothesis that vascular tone is increased in obesity through sympathetically medicated mechanisms. Weight loss is associated with a reduction in arterial pressure. They also hypothesize that decreased weight leads to a reduction in sympathetically mediated vascular tone and thus arterial pressure. This study will provide valuable information about control of vascular tone by the sympathetic nervous system in obesity and obesity related-hypertension. In addition, the results may suggest new approaches for prevention of the cardiovascular complications of obesity.