SYMPATHETIC CONTROL OF VASCULAR TONE IN OBESITY: INTERACTION WITH HYPERTENSION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。交感神经系统在肥胖中的作用是有争议的。许多动物研究报告交感神经活动减少。然而，交感神经激活已在人类肥胖中显示。还报道了对去甲肾上腺素的升压反应增强。关于交感神经系统对肥胖和肥胖相关高血压的基础血管张力的贡献，人们知之甚少。因此，这些研究者的目的是检验这一假设，即血管张力增加肥胖通过交感神经药物机制。 体重减轻与动脉压降低有关。他们还假设体重减轻导致交感神经介导的血管张力降低，从而导致动脉压降低。 本研究将为肥胖及肥胖相关高血压患者交感神经系统对血管张力的调控提供有价值的信息。此外，研究结果可能为预防肥胖的心血管并发症提供新的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The role of the sympathetic nervous system in obesity is controversial. Many studies in animals report decreased sympathetic nervous activity. However, sympathoactivation has been shown in human obesity. Enhanced pressor response to norepinephrine has also been reported. Little is known about the contribution of the sympathetic nervous system to basal vascular tone in obesity and in obesity-related hypertension. These investigators aim, therefore, to test the hypothesis that vascular tone is increased in obesity through sympathetically medicated mechanisms. Weight loss is associated with a reduction in arterial pressure. They also hypothesize that decreased weight leads to a reduction in sympathetically mediated vascular tone and thus arterial pressure. This study will provide valuable information about control of vascular tone by the sympathetic nervous system in obesity and obesity related-hypertension. In addition, the results may suggest new approaches for prevention of the cardiovascular complications of obesity.