EFFECT OF DIETARY FAT ON SYMPATHETIC NERVE ACTIVITY

膳食脂肪对交感神经活动的影响

• 批准号: 7376980
• 负责人: WILLIAM G HAYNES
• 金额: $ 1.92万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376980
• 关键词: EFFECT; DIETARY; FAT; SYMPATHETIC; NERVE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will clarify the mechanisms of sympathoactivation to meal ingestion. Insulin is known to induce sympathetic nervous system activation after carbohydrate administration but is not increased after fat ingestion. Thus, increases in sympathetic nerve activity (SNA) after a fat load would suggest the involvement of mediators other than insulin. These investigators propose to study the acute muscle and skin SNA response to oral fat, carbohydrate or water in lean and obese subjects.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究将阐明交感神经激活进食的机制。已知胰岛素在碳水化合物摄入后会诱导交感神经系统激活，但在脂肪摄入后不会增加。因此，脂肪负荷后交感神经活动(SNA)的增加可能表明胰岛素以外的介质参与其中。这些研究人员建议研究瘦和肥胖受试者对口服脂肪、碳水化合物或水的急性肌肉和皮肤SNA反应。