BASAL INSULIN DURING EXERCISE ON THE DEVELOPMENT OF HYPOGLYCEMIA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this study is to determine the effects of discontinuing a subject's basal rate during exercise on the glucose level during and following exercise. The study will consist of two outpatient visits each lasting approximately 7 hours with a 75-minute exercise session in the late afternoon. Assessment of changes in glucose concentrations, changes in hormone and plasma substrate concentrations during exercise will be performed. As part of the study the accuracy of a continuous glucose sensor during exercise will be assessed. The accuracy of a commercially-available home glucose meter will also be assessed.