NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。1型糖尿病（T1 D）是一种由胰腺β细胞破坏引起的疾病。它可以发生在任何年龄，但其发病率最高的是儿童和青少年。虽然所有人都是易感的，但T1 D患者的亲属患该病的风险要大得多。TrialNet T1 D发展自然史研究的目标是获得有关T1 D发病机制和自然史的信息，并促进招募和评估可能有资格参加T1 D预防试验的个人。重要的是，从这项研究中获得的信息将有助于制定和实施预防试验。本方案中描述的T1 D发展的TrialNet自然史研究的设计旨在实现这些目标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 1 diabetes (T1D) is a disease that results from the destruction of pancreatic beta-cells. It can occur at any age, but its incidence is highest in children and adolescents. Although all people are susceptible, relatives of individuals with T1D are at much greater risk for development of the disease. The goals of the TrialNet Natural History Study of the Development of T1D are to both gain information about the pathogenesis and natural history of T1D and to facilitate the recruitment and assessment of individuals who might qualify for T1D prevention trials. Importantly, the information obtained from this study will serve to enable the development and implementation of prevention trials. The design of the TrialNet Natural History Study of the Development of T1D as described in this protocol is intended to achieve these goals.