ALTERNATIVE STRESS MANAGEMENT APPROACHES IN HIV DISEASE

HIV 疾病的替代压力管理方法

• 批准号: 7375122
• 负责人: Nancy L McCain
• 金额: $ 11.66万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375122
• 关键词: ALTERNATIVE; STRESS; MANAGEMENT; APPROACHES; HIV

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A study to find interventions that are designed to reduce perceived stress and increase coping effectiveness in patients with HIV disease. A growing body of research with persons having HIV disease, as well as those with other chronic and potentially fatal illnesses such as cancer, indicates that a variety of biobehavioral strategies for stress management cannot only mitigate psychological distress and improve coping skills, but can also enhance immune function through neuroendocrine-immune system modulation. Such intervention strategies thus have considerable potential for lessening the amount of psychological and physical symptoms, thereby improving the quality of life of persons with HIV disease. While there is compelling evidence for neuroendocrine and behavioral interactions, especially stress effects with the immune system, the influences of these interactions on health outcomes is only beginning to be examined. Chronic and/or severe psychological stress associated with living with HIV disease may further compromise immune functioning over the illness progression, thereby increasing risks for morbidity and mortality. The three stress management interventions used by this study group are "positive living" (LIVE), Tai Chi (TCHI), and spiritual growth groups (SPRT). The aim is to determine if these three short-term interventions along with booster strategies will improve overall conditions for the patients. After strategies are used, data will be collected at the ten week mark, six months later, and twelve months later. Blood samples will be taken and patients will bring in saliva samples.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。一项旨在寻找旨在减少艾滋病毒患者感知压力和提高应对效率的干预措施的研究。越来越多的针对艾滋病患者以及其他慢性和潜在致命疾病（如癌症）患者的研究表明，各种用于压力管理的生物行为策略不仅可以减轻心理困扰和提高应对技能，还可以通过神经内分泌-免疫系统调节来增强免疫功能。因此，这种干预战略在减少心理和身体症状的数量，从而改善艾滋病毒感染者的生活质量方面具有相当大的潜力。虽然有令人信服的证据表明神经内分泌和行为相互作用，特别是压力对免疫系统的影响，但这些相互作用对健康结果的影响才刚刚开始被研究。与艾滋病毒感染者相关的慢性和/或严重心理压力可能在疾病进展过程中进一步损害免疫功能，从而增加发病率和死亡率的风险。本研究小组使用的三种压力管理干预措施是“积极生活”（LIVE），太极（TCHI）和精神成长小组（SPRT）。目的是确定这三种短期干预措施以及加强策略是否会改善患者的整体状况。使用策略后，将在10周、6个月和12个月后收集数据。血液样本将被采集，患者将携带唾液样本。