PNI-BASED STRESS MANAGEMENT IN EARLY BREAST CANCER

基于 PNI 的早期乳腺癌压力管理

• 批准号: 7717033
• 负责人: Nancy L McCain
• 金额: $ 6.26万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717033
• 关键词: Adjuvant Chemotherapy; Biological; Caring; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Data; Diagnostic Neoplasm Staging; Distress; Effectiveness; Fatigue; Funding; Grant; Growth; Health; Health Status; Human; Hydrocortisone; Immune; Immune System Diseases; Institution; Intervention; Interview; Leucine Enkephalin; Light; Malignant Neoplasms; Mediation; Neurosecretory Systems; Outcome; Participant; Pattern; Prognostic Nutritional Index; Purpose; Qualitative Methods; Quality of life; Research; Research Personnel; Resources; Science; Social support; Source; Spirituality; Standards of Weights and Measures; Stress; Stress and Coping; Structure; Symptoms; Tai Ji; Testing; Theoretical model; Training; United States National Institutes of Health; Woman; base; beta-Endorphin; body-mind; depressive symptoms; design; experience; malignant breast neoplasm; psychosocial; stress management

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall purpose of the proposed study is to determine whether two mind-body-spirit approaches for stress management will enhance psychosocial functioning, quality of life, and physical health among 240 women receiving adjuvant chemotherapy for early breast cancer (Stage I or II). The interventions, focused tai chi training (TCHI) and spiritual growth groups (SPRT), are designed to reduce perceived stress and enhance adaptational outcomes. AIM 1 is to compare the TCHI and SPRT interventions to each other and to a no-intervention (standard care) control group (NoIX) for effects on psychosocial functioning (perceived stress, coping patterns, spirituality, social support, inner strength, depressive symptoms, benefit finding), quality of life, neuroendocrine mediation (cortisol, beta-endorphin, leu-enkephalin), and physical health (immune status, symptom distress, and cancer-related health status, including fatigue). AIM 2 is to test the theoretical model for the study by examining the predicted relationships among the PNI-based indicators of psychosocial functioning (perceived stress, coping patterns, spirituality, social support, inner strength, depressive symptoms, benefit finding), quality of life, neuroendocrine mediation (cortisol, beta-endorphin, leu-enkephalin), and physical health (immune status, symptom distress, and cancer-related health status, including fatigue). Using qualitative methods, AIM 3 is to evaluate the experience of participating in the interventions through semi-structured interviews with a randomly selected subset of study participants. These data will be used to corroborate and amplify the quantitative data on psychosocial functioning, quality of life, symptom distress, and fatigue outcomes. As PNI-based research has grown, scientific evidence of associations among psychosocial, neuroendocrine, immunological, and disease-specific outcomes has continued to amass. However, the state-of-the-science is such that many PNI mechanisms remain unclear, particularly in the context of such complexity as is presented by human cancer and its treatments. Further, scientific evidence is far from convergence in the field of PNI in cancer. This study will shed light on certain hypothesized mechanisms as well as test the effectiveness of two promising mind-body-spirit interventions (Tai Chi and Spiritual Growth) on both psychobehavioral and biological outcomes

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 拟议研究的总体目的是确定两种身心压力管理方法是否会增强 240 名接受早期乳腺癌（I 期或 II 期）辅助化疗的女性的心理社会功能、生活质量和身体健康。 这些干预措施包括集中太极训练（TCHI）和精神成长小组（SPRT），旨在减少感知压力并增强适应结果。 目标 1 是比较 TCHI 和 SPRT 干预措施以及与无干预（标准护理）对照组 (NoIX) 对心理社会功能（感知压力、应对模式、灵性、社会支持、内在力量、抑郁症状、益处发现）、生活质量、神经内分泌调节（皮质醇、β-内啡肽、亮氨酸脑啡肽）和身体健康（免疫）的影响。 状态、症状困扰和癌症相关的健康状况，包括疲劳）。 目标 2 是通过检查基于 PNI 的心理社会功能指标（感知压力、应对模式、灵性、社会支持、内在力量、抑郁症状、益处发现）、生活质量、神经内分泌调节（皮质醇、β-内啡肽、亮氨酸脑啡肽）和身体健康（免疫状态、症状困扰和癌症相关）之间的预测关系来测试该研究的理论模型 健康状况，包括疲劳）。 AIM 3 使用定性方法，通过对随机选择的研究参与者子集进行半结构化访谈来评估参与干预的体验。这些数据将用于证实和放大有关心理社会功能、生活质量、症状困扰和疲劳结果的定量数据。 随着基于 PNI 的研究不断发展，社会心理、神经内分泌、免疫和特定疾病结果之间关联的科学证据不断积累。然而，目前的科学水平使得许多 PNI 机制仍不清楚，特别是在人类癌症及其治疗所呈现的复杂性背景下。此外，PNI 治疗癌症领域的科学证据还远未达到一致。这项研究将阐明某些假设的机制，并测试两种有前途的身心精神干预措施（太极拳和精神成长）对心理行为和生物学结果的有效性