PNI-BASED STRESS MANAGEMENT IN EARLY BREAST CANCER

基于 PNI 的早期乳腺癌压力管理

• 批准号: 7375172
• 负责人: Nancy L McCain
• 金额: $ 0.7万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375172
• 关键词: PNI; BASED; STRESS; MANAGEMENT; EARLY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall purpose of the proposed study is to determine whether two mind-body-spirit approaches for stress management will enhance psychosocial functioning, quality of life, and physical health among 240 women receiving adjuvant chemotherapy for early breast cancer (Stage I or II). The interventions, focused tai chi training (TCHI) and spiritual growth groups (SPRT), are designed to reduce perceived stress and enhance adaptational outcomes. AIM 1 is to compare the TCHI and SPRT interventions to each other and to a no-intervention (standard care) control group (NoIX) for effects on psychosocial functioning (perceived stress, coping patterns, spirituality, social support, inner strength, depressive symptoms, benefit finding), quality of life, neuroendocrine mediation (cortisol, beta-endorphin, leu-enkephalin), and physical health (immune status, symptom distress, and cancer-related health status, including fatigue). AIM 2 is to test the theoretical model for the study by examining the predicted relationships among the PNI-based indicators of psychosocial functioning (perceived stress, coping patterns, spirituality, social support, inner strength, depressive symptoms, benefit finding), quality of life, neuroendocrine mediation (cortisol, beta-endorphin, leu-enkephalin), and physical health (immune status, symptom distress, and cancer-related health status, including fatigue). Using qualitative methods, AIM 3 is to evaluate the experience of participating in the interventions through semi-structured interviews with a randomly selected subset of study participants. These data will be used to corroborate and amplify the quantitative data on psychosocial functioning, quality of life, symptom distress, and fatigue outcomes. As PNI-based research has grown, scientific evidence of associations among psychosocial, neuroendocrine, immunological, and disease-specific outcomes has continued to amass. However, the state-of-the-science is such that many PNI mechanisms remain unclear, particularly in the context of such complexity as is presented by human cancer and its treatments. Further, scientific evidence is far from convergence in the field of PNI in cancer. This study will shed light on certain hypothesized mechanisms as well as test the effectiveness of two promising mind-body-spirit interventions (Tai Chi and Spiritual Growth) on both psychobehavioral and biological outcomes

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项拟议研究的总体目的是确定两种心理-身体-精神压力管理方法是否会增强240名接受早期乳腺癌（I期或II期）辅助化疗的妇女的心理社会功能，生活质量和身体健康。这些干预措施，重点太极训练（TCHI）和精神成长团体（SPRT），旨在减少感知压力和增强适应效果。 目的1是比较TCHI和SPRT干预相互之间以及无干预（标准护理）对照组（NoIX），用于评估对心理社会功能的影响（感知压力、应对模式、灵性、社会支持、内在力量、抑郁症状、利益发现）、生活质量、神经内分泌调节（皮质醇，β-内啡肽，亮脑啡肽）和身体健康（免疫状态，症状困扰和癌症相关的健康状况，包括疲劳）。 目的2是通过检验基于PNI的心理社会功能指标之间的预测关系来检验研究的理论模型（感知压力、应对模式、灵性、社会支持、内在力量、抑郁症状、利益发现）、生活质量、神经内分泌调节（皮质醇，β-内啡肽，亮脑啡肽）和身体健康（免疫状态，症状困扰和癌症相关的健康状况，包括疲劳）。 AIM 3采用定性方法，通过与随机选择的研究参与者子集进行半结构化访谈，评估参与干预措施的经验。这些数据将用于证实和放大有关心理社会功能、生活质量、症状困扰和疲劳结局的定量数据。 随着基于PNI的研究的发展，社会心理、神经内分泌、免疫学和疾病特异性结果之间相关性的科学证据不断积累。然而，目前的科学水平使得许多PNI机制仍然不清楚，特别是在人类癌症及其治疗所呈现的复杂性的背景下。此外，科学证据在癌症的PNI领域还远未达到一致。本研究将阐明某些假设的机制，并测试两种有前途的身心干预（太极和精神成长）对心理行为和生物结果的有效性