BIOBEHAVIORAL RESEARCH IN CRITICAL HEALTH EXPERIENCES

描述（由申请人提供）：拟议的生物行为临床研究探索/发展中心（CBCR）的目的是加强与弗吉尼亚联邦大学护理学院改善与关键健康经验相关的生物行为结果相关的研究项目。在生理和心理两方面的关键健康经验的背景下，始终注重生物和行为变量与健康结果的综合，将为更全面地理解健康-疾病现象和护理干预措施提供重要机会。研究生物和行为因素的整合或提供对整个人的独特理解将推进整体护理知识，这对理解关键的健康经历至关重要。目前和计划中的中心研究将集中在生物和行为变量的相互作用上。生物学变量包括微生物学、免疫学、神经学、心肺学和神经内分泌方面的健康。行为变量包括心理行为、精神和健康的发展方面。拟议中心的一个独特重点是在关键卫生经验的背景下审查这些变量之间的相互作用。重大健康经历涉及健康方面的巨大变化或对健康变化的看法，使个人处于危险之中。试点研究的具体目标将包括与目前资助的项目一致的生物和行为因素的调查。试点研究还可包括调查，以确定不良生物行为结果的风险因素，以及测试可能影响护理敏感生物行为健康结果的干预策略。该中心将提供当前结构无法提供的资源和服务协调。共享设备（如数据采集系统）和服务（如实验室测试和数据管理）将提高资源的使用效率。建立CBCR核心实验室将提高新的和现有的研究人员直接获得实验室服务的能力，而这些服务可能无法通过其他方式获得，并且与合同服务相比，可以对测量进行更大的控制。

DESCRIPTION (provided by applicant): The purpose of the proposed Exploratory/Developmental Center for Biobehavioral Clinical Research (CBCR) is to enhance the research programs related to improving biobehavioral outcomes associated with critical health experiences at Virginia Commonwealth University School of Nursing. A consistent focus on the integration of biological and behavioral variables and health outcomes in the context of critical health experiences, both physical and psychological, will provide significant opportunities for more holistic understandings of the phenomena of health-illness and nursing interventions. Research examining the integration of biological and behavioral factors or providing unique understanding of the whole person will advance holistic nursing knowledge essential to the understanding of critical health experiences. Current and proposed Center studies will focus on the interaction of biological and behavioral variables. Biological variables include microbiological, immunological, neurological, cardiopulmonary, and neuroendocrine aspects of health. Behavioral variables include psychobehavioral, spiritual, and developmental aspects of health. A unique focus of the proposed Center is the examination of the interaction among these variables in the context of critical health experiences. A critical health experience involves a dramatic change in health or a perception of change in relation to health that places an individual at risk. Specific aims of pilot studies will include investigation of biological and behavioral factors consistent with currently funded programs. Pilot studies also may include investigations to identify risk factors for adverse biobehavioral outcomes as well as to test intervention strategies that may impact nursing-sensitive biobehavioral health outcomes. The Center will provide coordination of resources and services that is not possible in the current Mastructure. Sharing of equipment (such as data acquisition systems) and services (such as laboratory testing and data management) will provide efficiency in use of resources. Establishment of the CBCR Core Laboratory will enhance the ability of new and established researchers to directly access laboratory services that may not be available otherwise, and to exercise greater control over measurement than is possible with contracted services.