250 MICROGRAM ACTH STIMULATION TEST IN PREGNANCY

妊娠期 250 微克 ACTH 刺激试验

• 批准号: 7378634
• 负责人: ROY E WEISS
• 金额: $ 1.26万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378634
• 关键词: adrenal glands; aldosterone; cortisol; plasma; pregnancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is hypothesized that pregnant women have significantly elevated total and free cortisol levels and plasma aldosterone concentrations (in comparison to non-pregnant women), and that these levels will increase as pregnancy progresses. It is hypothesized that there will be an increased responsiveness of the adrenal glands to synthetic ACTH in pregnancy, and that particularly free cortisol response to synthetic ACTH will increase as prenancy progresses.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。据推测，孕妇的总皮质醇和游离皮质醇水平以及血浆中的醛固酮浓度显著升高(与未怀孕妇女相比)，并且这些水平会随着怀孕的进展而增加。假设妊娠期间肾上腺对合成ACTH的反应性增强，尤其是对合成ACTH的游离皮质醇反应会随着妊娠进展而增加。