THE ROLE OF CORTISOL IN GESTATIONAL DIABETES MELLITUS

皮质醇在妊娠糖尿病中的作用

• 批准号: 7378636
• 负责人: ROY E WEISS
• 金额: $ 0.63万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378636
• 关键词: cortisol; gestational diabetes mellitus; glucose tolerance; hypercortisolism; insulin sensitivity /resistance; role; secretion; tissues

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pregnant Women with gestational diabetes mellitus (GDM) will have an attenuation in their hypothalamic-pituitary-adrenal (H-P-A) axis which results in elevated total and free morning cortisol levels, discrete elevations in cortisol secretion throughout the day, and altered tissue response to cortisol. It is hypothesized that this functional hypercortisolism contributes to the increased insulin resistance seen in pregnant women with GDM versus normal glucose tolerance pregnant women.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。妊娠糖尿病（GDM）的孕妇将在下丘脑 - 垂体 - 肾上腺（H-P-A）轴上衰减，这会导致总皮质醇水平升高和免费的早晨皮质醇水平，整天皮质醇分泌的离散升高，并改变对皮质醇的组织反应。假设这种功能性超皮质醇主义有助于GDM孕妇与正常葡萄糖耐受性孕妇的胰岛素抵抗增加。