THE ROLE OF CORTISOL IN GESTATIONAL DIABETES MELLITUS

皮质醇在妊娠糖尿病中的作用

• 批准号: 7378636
• 负责人: ROY E WEISS
• 金额: $ 0.63万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378636
• 关键词: cortisol; gestational diabetes mellitus; glucose tolerance; hypercortisolism; insulin sensitivity /resistance; role; secretion; tissues

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pregnant Women with gestational diabetes mellitus (GDM) will have an attenuation in their hypothalamic-pituitary-adrenal (H-P-A) axis which results in elevated total and free morning cortisol levels, discrete elevations in cortisol secretion throughout the day, and altered tissue response to cortisol. It is hypothesized that this functional hypercortisolism contributes to the increased insulin resistance seen in pregnant women with GDM versus normal glucose tolerance pregnant women.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。妊娠期糖尿病(GDM)孕妇的下丘脑-垂体-肾上腺(H-P-A)轴将减弱，导致总皮质醇水平和早上自由皮质醇水平升高，全天皮质醇分泌离散升高，组织对皮质醇的反应改变。据推测，与糖耐量正常的孕妇相比，这种功能性皮质醇增多导致妊娠期糖尿病孕妇的胰岛素抵抗增加。