STUDIES OF CUSHING'S DISEASE

库欣病的研究

• 批准号: 7604780
• 负责人: ROY E WEISS
• 金额: $ 1.07万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604780
• 关键词: Adrenal Gland Hyperfunction; Computer Retrieval of Information on Scientific Projects Database; Condition; Corticotropin; Cushing Syndrome; Dexamethasone; Diagnosis; Etiology; Funding; Glucocorticoids; Grant; Hour; Hydrocortisone; Institution; Methods; Obesity; Pituitary-dependent Cushing' s disease; Plasma; Research; Research Personnel; Resources; Salivary; Serum; Sleep; Sleep Apnea Syndromes; Source; Testing; United States National Institutes of Health; improved; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determination of the underlying etiology of hypercortisolism is extremely challenging due to the nonspecificity of available tests. Consequently, the treatment currently offered for this highly morbid condition is unsuccessful in 20-25% of subjects. We propose that analysis of the 24 hour secretory profile of salivary cortisol, serum cortisol, and plasma ACTH will provide sensitive markers for the correct diagnosis of the etiology of hypercortisolism. In addition, sleep-disordered breathing (SDB) is common in subjects with Cushing s syndrome. It is unclear whether the SDB results from the associated obesity or whether there is a direct effect of the glucocorticoids on sleep centers. We hypothesize that (1) the use of salivary cortisol 24 hour profile as well as salivary response to CRF stimulation with or without dexamethasone is an accurate method of diagnosing Cushing s syndrome and (2) the correction of the hypercortisolism will improve the SDB seen in Cushing s syndrome.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 由于现有检测方法的非特异性，确定皮质醇增多症的潜在病因极具挑战性。因此，目前针对这种高度病态疾病提供的治疗在20-25%的受试者中不成功。 我们建议，唾液皮质醇，血清皮质醇，血浆促肾上腺皮质激素的24小时分泌曲线的分析将提供敏感的标志物，正确诊断皮质醇增多症的病因。此外，睡眠呼吸障碍（SDB）在患有库欣综合征的受试者中很常见。 目前还不清楚SDB是否由相关的肥胖引起，或者糖皮质激素是否对睡眠中心有直接影响。 我们假设（1）使用唾液皮质醇24小时曲线以及唾液对CRF刺激（有或无地塞米松）的反应是诊断库欣综合征的准确方法，（2）皮质醇增多症的纠正将改善库欣综合征中观察到的SDB。