Effect of ultra short-acting β1-adrenergic receptor blocker on cardiac muscle as an immunomodulation therapy under excessive stress.

方法：对30例SIRS所致快速心室反应的阵发性心房颤动患者静脉注射选择性β1受体阻滞剂兰地洛尔，记录心率、血压变化，测定心脏指数等血流动力学参数，并检测血清炎性细胞因子水平。接下来，我们比较了兰地洛尔、地高辛、西苯唑啉和维拉帕米对由SIRS引起的阵发性房颤和快速心室反应患者的作用。兰地洛尔确实降低了心率，但不会导致血压大幅下降。兰地洛尔降低心脏指数，但增加每搏输出量指数。兰地洛尔降低血清白细胞介素-6水平。兰地洛尔降低心率的作用大于其他药物。兰地洛尔的降压作用与西苯唑啉和维拉帕米相当。兰地洛尔的药物复律成功率高于地高辛或维拉帕米，与环苯唑啉相近。

Patients of paroxysmal atrial fibrillation with a rapid ventricular response caused by SIRS were injected with landiolol, a short-acting selective β1-adrenergic receptor blocker and the changes in heart rate and blood pressure were recorded, hemodynamic parameters including cardiac index were measured, and the serum levels of inflammatory cytokines were measured. Next, we compared the effects of landiolol, digoxin, cibenzoline, and verapamil for patients with paroxysmal atrial fibrillation and a rapid ventricular response caused by SIRS. Landiolol certainly decreased the heart rate without inducing a massive decline in blood pressure. Landiolol decreased cardiac index, but increased the stroke volume index. Landiolol decreased the serum levels of interleukin-6. Landiolol decreased the heart rate more than the other drugs. The blood pressure lowering effect of landiolol was comparable to those of cibenzoline and verapamil. The success rate of pharmacological cardioversion using landiolol was higher than that using digoxin or verapamil, and was nearly equal to that using cibenzoline.