ASSESS CARDIOVASCULAR RISK ON A HIGH PROTEIN, LOW CARB DIET COMP W/USDA DIET

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项研究高碳水化合物和低碳水化合物饮食如何影响患心脏病的某些风险因素。为了调查这一点，我们将进行三次24小时喂养研究。在每24小时内，我们将特别关注两件事：当你按照指定的饮食习惯进食时，血液中循环的一种胆固醇（称为残余脂蛋白）的水平。进食后的血管功能，同样在这3天进行评估。第一项研究将在开始指定饮食之前进行。在这个时候，受试者将吃相同类型的饮食，与美国农业部的建议一致。第二项研究将在开始指定饮食后8-12周进行，研究期间所吃的食物将与指定饮食一致。第三项研究也将与指定的饮食保持一致，并将在每个人达到体重稳定且不再减肥的程度时进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a study looking at how a high carbohydrate versus a low carbohydrate diet affects certain risk factors for developing heart disease. To investigate this, we will perform three 24-hour feeding studies. During each 24-hour period, we will specifically look at 2 things: 1.) Levels of a type of cholesterol in the blood (called remnant lipoproteins) circulating in the bloodstream while eating food consistent with your assigned diet and, 2.) Function of blood vessels after eating, assessed on these same 3 days. The first study will be done before starting the assigned diet. At this time, subjects will eat the same type of diet, one that is consistent with USDA recommendations. The second study will be done 8-12 weeks after starting the assigned diet and food eaten during the study will be consistent with the assigned diet. The 3rd study will also be consistent with the assigned diet and will be done when each person has reach a point where his/her weight has stabilized and he/she is no longer losing weight.