Obesity and Cardiovascular Disease: Opportunity for Post-Doctoral Training

描述(由申请人提供)：这份提交给NHLBI的T32拨款申请是一份新的申请，旨在支持科罗拉多大学安舒茨医学院(UCAMC)和相关机构(包括芭芭拉·戴维斯儿童糖尿病中心、科罗拉多大学博尔德分校(UCB)、丹佛健康、丹佛退伍军人管理局医学中心(VAMC)和国家犹太人健康中心(NJH))在肥胖和心血管疾病(CVD)科学方面的博士后研究培训。培训计划的目的是新颖、广泛和全面的，包括基础、临床和人口科学机会如何与心血管疾病有关。重点培训的领域将包括高血压、糖尿病、阻塞性睡眠呼吸暂停和哮喘、充血性心力衰竭(CHF)、冠心病(CHD)、脑血管疾病和猝死。培训还将侧重于肥胖症的治疗和预防。在第一年申请2个名额，到第三年申请在两年培训期间分配总共4个名额。第三年的选择权将由学员的导师负责。虽然重点将放在内科科学家身上，但4个名额中约有1个将用于博士研究生，特别强调与肥胖和心血管疾病相关的翻译研究。UCAMC已投资250多万美元建立了一个新的肥胖研究所(科罗拉多肥胖研究所，CORI)，该研究所拥有100多名教职员工。在这些人中，33人已被确定为导师/导师，其中包括高级和职业生涯中期的调查人员，其中许多人是国内和国际公认的肥胖和心血管疾病科学领域的领导者。据我们所知，美国没有其他项目有这方面的重点，在目前肥胖在整个发达国家和发展中国家流行的环境下，需要有针对性的高级培训，了解肥胖与心血管疾病的关系是非常及时的。通过这项计划招募、培养和发展学术肥胖/心血管疾病翻译科学家的目标将完全依赖于NHLBI的培训拨款。

DESCRIPTION (provided by applicant): This T32 grant application submitted to NHLBI is a new application to support post-doctoral research training in the science of obesity and cardiovascular disease (CVD) at the University of Colorado Anschutz Medical Campus (UCAMC) and related institutions including the Barbara Davis Center for Childhood Diabetes, University of Colorado at Boulder (UCB), Denver Health, the Denver Veterans Administration Medical Center (VAMC), and the National Jewish Health (NJH). The intent of the training program is novel, broad-based and comprehensive including basic, clinical, and population science opportunities on how obesity relates to CVD. Areas of focused training will include hypertension, diabetes, obstructive sleep apnea and asthma, congestive heart failure (CHF), coronary heart disease (CHD), cerebrovascular disease, and sudden death. Training will also be focused on treatment and prevention of obesity. During the first year 2 slots are requested, and by the 3rd year a total of 4 slots divided between the two years of training are requested. An option for a third year will be the responsibility of the trainee's mentor. Although the emphasis will be placed on physician scientists, approximately 1 of the 4 slots will be used for a PhD fellow with a specific emphasis on translational research related to obesity and CVD. The UCAMC has invested over 2.5 million dollars into a new obesity institute (Colorado Obesity Research institute, CORI) that encompasses more than 100 faculty. Of these, 33 have been identified as preceptors/mentors and include senior and mid-career investigators many of whom are nationally and internationally recognized leaders in obesity and CVD science. To our knowledge there is no other program in the USA that has this focus, and in the current environment of the epidemic of obesity throughout the developed and developing world the need for targeted advanced training in how obesity relates to CVD is more than timely. The goal of recruiting, fostering and developing academic obesity/CVD translational scientists through this program will be completely dependent on this NHLBI training grant.