Obesity and Cardiovascular Disease: Opportunity for Post-Doctoral Training

描述（由申请人提供）：提交给 NHLBI 的 T32 拨款申请是一项新申请，旨在支持科罗拉多大学安舒茨医学校区 (UCAMC) 以及相关机构（包括芭芭拉戴维斯儿童糖尿病中心、科罗拉多大学博尔德分校 (UCB)、丹佛健康中心、丹佛退伍军人管理局医疗中心 (VAMC) 和国家犹太健康中心 (NJH)）在肥胖和心血管疾病 (CVD) 科学方面的博士后研究培训。该培训计划的目的新颖、基础广泛且全面，包括有关肥胖与心血管疾病之间关系的基础、临床和人口科学机会。重点培训领域包括高血压、糖尿病、阻塞性睡眠呼吸暂停和哮喘、充血性心力衰竭（CHF）、冠心病（CHD）、脑血管疾病和猝死。培训还将侧重于肥胖的治疗和预防。第一年申请 2 个名额，到第三年，两年培训期间总共申请 4 个名额。第三年的选择将由受训者的导师负责。尽管重点将放在医师科学家身上，但 4 个名额中大约有 1 个将用于博士研究员，特别强调与肥胖和心血管疾病相关的转化研究。 UCAMC 投资超过 250 万美元建立了一个新的肥胖研究所（科罗拉多肥胖研究所，CORI），该研究所拥有 100 多名教职人员。其中，33 人被确定为指导者/导师，包括高级和中期职业研究人员，其中许多人是国内和国际公认的肥胖和心血管疾病科学领域的领导者。据我们所知，美国没有其他项目关注这一重点，并且在当前肥胖在发达国家和发展中国家流行的环境下，有针对性地进行有关肥胖与心血管疾病之间关系的高级培训的必要性非常及时。通过该计划招募、培养和发展学术肥胖/CVD 转化科学家的目标将完全依赖于 NHLBI 的培训拨款。

DESCRIPTION (provided by applicant): This T32 grant application submitted to NHLBI is a new application to support post-doctoral research training in the science of obesity and cardiovascular disease (CVD) at the University of Colorado Anschutz Medical Campus (UCAMC) and related institutions including the Barbara Davis Center for Childhood Diabetes, University of Colorado at Boulder (UCB), Denver Health, the Denver Veterans Administration Medical Center (VAMC), and the National Jewish Health (NJH). The intent of the training program is novel, broad-based and comprehensive including basic, clinical, and population science opportunities on how obesity relates to CVD. Areas of focused training will include hypertension, diabetes, obstructive sleep apnea and asthma, congestive heart failure (CHF), coronary heart disease (CHD), cerebrovascular disease, and sudden death. Training will also be focused on treatment and prevention of obesity. During the first year 2 slots are requested, and by the 3rd year a total of 4 slots divided between the two years of training are requested. An option for a third year will be the responsibility of the trainee's mentor. Although the emphasis will be placed on physician scientists, approximately 1 of the 4 slots will be used for a PhD fellow with a specific emphasis on translational research related to obesity and CVD. The UCAMC has invested over 2.5 million dollars into a new obesity institute (Colorado Obesity Research institute, CORI) that encompasses more than 100 faculty. Of these, 33 have been identified as preceptors/mentors and include senior and mid-career investigators many of whom are nationally and internationally recognized leaders in obesity and CVD science. To our knowledge there is no other program in the USA that has this focus, and in the current environment of the epidemic of obesity throughout the developed and developing world the need for targeted advanced training in how obesity relates to CVD is more than timely. The goal of recruiting, fostering and developing academic obesity/CVD translational scientists through this program will be completely dependent on this NHLBI training grant.