2018 Kern Lipid Conference

2018年科恩脂质会议

• 批准号: 9610114
• 负责人: Robert H Eckel
• 金额: $ 1.95万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9610114
• 关键词: ATP Citrate (pro-S)-Lyase; Academia; Acetates; Acetyl-CoA Carboxylase; Acids; Address; Adipocytes; Antitumor Response; Atherosclerosis; Award; Basic Science; Blood capillaries; CD8-Positive T-Lymphocytes; California; Cells; Cellular Metabolic Process; Cholesterol Homeostasis; Clinical Research; Computer Simulation; Disease; Doctor of Philosophy; Endothelial Cells; Endothelium; Epigenetic Process; Explosion; FRAP1 gene; Faculty; Family suidae; Fatty Acids; Fatty Liver; Fostering; Genetic; Genomics; Goals; Health; Hepatic; Hepatocyte; Histone Acetylation; Homeostasis; Human; Immune; Immune system; Immunity; Industry; Inflammatory; Institutes; Insulin; Insulin Receptor; International; Investigation; Ketone Bodies; LDL Cholesterol Lipoproteins; Lead; Lipids; Liver; Low Density Lipoprotein Receptor; Malignant Neoplasms; Maps; Massachusetts; Medicine; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolism; Minnesota; Molecular; Mus; Muscle; Muscle Cells; Natural Immunity; New York; Nutrient; Obesity; Ontario; Oral; Organ; Participant; Pathway interactions; Patients; Pennsylvania; Permeability; Phenotype; Plasma; Process; Regulation; Research; Research Personnel; Role; Safety; Science; Scientist; Signal Transduction; Skeletal Muscle; Source; System; T-Lymphocyte; Technology; Therapeutic; Therapeutic Uses; Time; Tissues; Translational Research; Triglycerides; Universities; Validation; Vascular Endothelial Growth Factors; Vasculitis; Warburg Effect; Washington; authority; base; bench to bedside; blood glucose regulation; body system; cancer therapy; cardiometabolism; career; detection of nutrient; improved; inhibitor/antagonist; insight; insulin sensitivity; lectures; lipid biosynthesis; lipid metabolism; lipid transport; medical schools; meetings; member; metabolomics; new therapeutic target; novel; novel strategies; novel therapeutic intervention; novel therapeutics; posters; programs; symposium; therapeutic target; translational scientist; translational study

Abstract: Since its inception in 1985, the goals of the Kern Lipid Conference have been to promote metabolic science and increase understanding of metabolic pathobiology. The conference strives to provide an inclusive, open forum for established and young emerging scientists from academia and industry. The 2018 Kern Lipid Conference chaired by Nada Abumrad, Susan Kaech and Roger Newton will have as theme “Metabolic Regulation of Immunity, Cardio-metabolic Disease, and Cancer: New Therapeutic Approaches.” The 2018 conference's goal is to provide a dynamic interactive process that leads to novel insights into disease mechanisms involving metabolic reprogramming across organs. Specifically nutrient sensing and metabolic remodeling by immune and endothelial cells/systems but also by liver, muscle and adipose cells/tissues will be examined with a focus on pathways that have the potential to lead to new therapies. The program will cover basic and translational science targeting novel therapeutics that benefit patients with dysfunctional immune systems, cardio-metabolic disorders or that improve efficacy and safety of cancer treatments. Three daily sessions with 25 confirmed speakers will be followed by three evening poster sessions. Breaks, lunches and a closing dinner on the premises promote interactions between participants. Idea exchange is maximized by allocating ample time for questions after didactic presentations and through fostering discussion by session chairs and other attending Kern board members. The Conference traditionally attracts early career scientists (~40%) and established scholars as well as creative scientists from industry. Participation of young scientists is strongly promoted by including them among the invited speakers; in 2018, 11 of the invited speakers are early careers investigators with two young investigators to be selected as recipients of the competitive prestigious awards, David L Williams and Roger Davis Lectureships. The setting and meeting format which facilitate interaction and discussion, the confirmed participation of internationally recognized authorities (e.g. David Sabatini, Reuben Shaw, Peter Carmeliet) inclusion of young emerging stars (e.g. Kathryn Wellen, Jason Locasale, Lydia Lynch) and translational researchers (Gregory Steinberg, Jay Horton), make it likely that novel insights into disease mechanisms and therapeutic approaches for immune and cardio-metabolic Disease and Cancer will emerge from the 2018 Conference.

摘要： 自1985年成立以来，克恩脂质会议的目标一直是促进代谢科学 并增加对代谢病理学的理解。会议力求提供一个包容、开放、 为来自学术界和工业界的老牌和年轻新兴科学家举办的论坛。2018年克恩脂质 会议由Nada Abumrad，Susan Kaech和Roger Newton主持，主题为“代谢 免疫调节，代谢性疾病和癌症：新的治疗方法。的 2018年会议的目标是提供一个动态的互动过程，导致对疾病的新见解 涉及器官间代谢重编程的机制。特别是营养传感和代谢 免疫和内皮细胞/系统以及肝脏、肌肉和脂肪细胞/组织的重塑将是 研究的重点是有可能导致新疗法的途径。该计划将涵盖 基础科学和转化科学，目标是使免疫功能障碍患者受益的新型疗法 系统、心脏代谢紊乱或改善癌症治疗的功效和安全性。一日三 在25名已确认的发言者的会议之后，将举行三次晚间海报会议。休息、午餐和 闭幕晚宴促进了与会者之间的互动。思想交流最大化， 在教学性演讲后，通过促进讨论，为问题分配充足的时间 主席和其他出席克恩董事会成员。该会议传统上吸引了早期的职业科学家 （约40%）和知名学者以及来自行业的创意科学家。青年科学家的参与是 通过将他们包括在受邀演讲者中来大力推广; 2018年，11位受邀演讲者提前 职业调查员与两名年轻的调查员被选为具有竞争力的著名的 奖项，大卫L威廉姆斯和罗杰戴维斯讲座。会议的安排和形式， 互动和讨论，国际公认的权威机构（如大卫）的确认参与 萨巴蒂尼、鲁本·肖、彼得·卡米利埃）包括年轻的新星（如凯瑟琳·韦伦、杰森· Locasale，Lydia Lynch）和翻译研究人员（Gregory Steinberg，Jay Horton），使小说 深入了解免疫和心脏代谢疾病的疾病机制和治疗方法， 癌症将在2018年会议上出现。