MECHANISMS DEFENDING FAT MASS IN HUMANS AFTER LIPECTOMY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. No one is sure that the fat removed by liposuction is permanent. The purpose of this study is to answer this question. We will explore the possibility that genetics and metabolism contribute to the response of fat removal by liposuction. Fat biopsies will be carried out before and twice more after liposuction to determine what genes are expressed and how their expression predicts and/or relates to changes in body fat at the liposuction site and elsewhere in the body. Two groups of subjects will participate. The first group will be examined before and up to 3 years after liposuction, whereas the second group will have similar measurements over 3 years but no liposuction. However, the group of subjects who do not receive liposuction during the study period will have an opportunity to have liposuction performed after 3 years at a reduced cost. This study will help to answer an important question about a common cosmetic surgery that may provide additional insights into how body fat is regulated in humans.