CEREBELLAR SYNDROMES: CLINICAL AND EXPERIMENTAL STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们研究的最终目标是将来自广泛疾病实体的结构和功能数据纳入多维概率图谱，我们将验证该工具作为小脑功能的替代测量。这本质上是一个面向解剖学的数据库，包含临床、遗传和生理数据以及形态测量数据。该框架适用于多个功能领域的查询，我们的研究沿着三条相交的路径进行，以验证既广泛又深入的描述符。在这里，我们提出了一个综合的7年计划，将在精心挑选的疾病队列中使用图谱的初步公式来回答小脑结构-功能关系的长期问题，然后开发一种自动图像分析的方法，使图谱能够得到广泛使用。这是一项巨大的事业，但鉴于JHMI丰富的设备资源，我们从神经病学、精神病学、放射学、生物医学工程、电气和计算机工程等部门汇集的专业知识和努力，以及我们丰富的患者转介基础，我们处于独特的地位，能够完成这项任务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The eventual goal of our research is to incorporate structural and functional data from a broad range of disease entities into a multidimensional probabilistic atlas, a tool that we will validate as a surrogate measure of cerebellar function. This is essentially an anatomically oriented database incorporating clinical, genetic, and physiologic data as well as morphometric data. This framework is suited to inquiry in multiple functional domains, and our study is directed along three intersecting paths in order to validate descriptors that are both broad and deep. Here we present an integrated 7-year plan that will use an initial formulation of the atlas in carefully selected disease cohorts to answer longstanding questions of structure-function relationship in the cerebellum, then develop a method for automated image analysis that will enable widespread use of the atlas. This is a tremendous undertaking, but given the extensive equipment resources of the JHMI, the expertise and effort we have assembled from the Departments of Neurology, Psychiatry, Radiology, Biomedical Engineering, and Electrical and Computer Engineering, and our rich patient referral base, we are uniquely positioned to accomplish this task.