NEUROIMAGING, NEUROPSYCHIATRY, AND COGNITIVE FUNCTIONING

神经影像学、神经精神病学和认知功能

• 批准号: 7378949
• 负责人: SARAH A READING
• 金额: $ 0.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378949
• 关键词: NEUROIMAGING; NEUROPSYCHIATRY; COGNITIVE; FUNCTIONING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will refine existing functional MRI (fMRI) paradigms to assess basal ganglia activity in presymptomatic persons with the Huntington's Disease (HD) mutation during tasks involving implicit learning of fine motor tasks. We hypothesize (a) that fMRI tasks involving implicit learning of motor sequences will differentiate individuals at the presymptomatic stages of HD from age, sex, handedness and race- matched individuals who do not carry the HD gene and (b) that correlations will exist between activation level of the putamen and extent of implicit learning. This work will directly address the question of when functional, as opposed to structural basal ganglia abnormalities begin in HD, which may be a good indicator of when treatment should begin (especially assuming that the treatment may be costly or have undesirable side effects). Data from this project will also be valuable in the design of future treatment trials. Such treatment trials are currently underway with symptomatic HD patients, and it is reasonable to assume that trials with presymptomatic carriers of the HD gene will occur immediately following the identification of the first successful treatment within the symptomatic population. Our previous longitudinal MRI studies with symptomatic and presymptomatic individuals provide preliminary data suggesting that volumetric MRI measures of basal ganglia may serve as excellent outcome measures for such treatment trials, especially within the presymptomatic population for whom measures of symptom severity cannot be used. We hypothesize that functional MRI measures may be even more sensitive to the earliest changes in basal ganglia in the presymptomatic stages in HD.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们将完善现有的功能磁共振成像（fMRI）的范例，以评估基底神经节的活动与亨廷顿氏病（HD）突变的前驱的人在涉及精细运动任务的内隐学习的任务。我们假设：（a）涉及运动序列内隐学习的fMRI任务将区分处于HD症状前阶段的个体与年龄、性别、利手和种族匹配的不携带HD基因的个体;（B）壳核激活水平与内隐学习程度之间存在相关性。这项工作将直接解决功能性基底神经节异常何时开始的问题，而不是结构性基底神经节异常开始的HD，这可能是一个很好的指标，何时治疗应该开始开始（特别是假设治疗可能是昂贵的或有不良的副作用）。来自该项目的数据也将在未来治疗试验的设计中具有价值。目前正在对有症状的HD患者进行此类治疗试验，可以合理地假设，在有症状人群中首次成功治疗后，将立即对HD基因的症状前携带者进行试验。我们之前对症状和症状前个体的纵向MRI研究提供了初步数据，表明基底神经节的体积MRI测量可能作为此类治疗试验的良好结局指标，特别是在症状严重程度无法测量的症状前人群中。我们推测，功能性磁共振成像的措施可能是更敏感的最早的变化，基底神经节在症状前阶段的HD。