ANTIRETROVIRAL THERAPY ON BODY COMPOSITION IN HIV-INFECTED CHILDREN

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Wasting syndrome is a significant contributor to mortality in HIV-infected children. Little information is available on body composition in HIV-infected children or changes upon institution of antiretroviral therapy, and the relationship between growth and viral load remains unclear. PACTG 1010 is a multi-site observational trial supported by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Child Health and Human Development (NICHD), NIH, through the Pediatric Clinical Trials Cooperative Group. It is an observational study measuring body composition, growth and nutritional parameters in pre-puberty children with HIV infection. Numerous parameters (blood levels, bioelectrical impedance analysis, body measures, etc) will be obtained in patients at various stages of disease. Antiretroviral responders will be compared with non-responders. As of January 3, 2003, the study has accrued 70 subjects, nine subjects into Stratum A (1 to 18 months of age), 12 subjects into Stratum B (older than 18 months to three years of age), 24 into Stratum C (older than three years to eight years of age), 25 into Stratum D (older than eight years to 13 years of age). Subjects continue to be recruited for the study.