ACTG 219: PEDIATRIC LATE OUTCOMES (AIDS)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 有必要更好地评估对儿童进行的各种抗艾滋病毒治疗的积极和消极的后期后果。本研究旨在收集前瞻性纵向数据，以确定1）与HIV疾病进展、治疗或预防性干预和/或HIV疾病与治疗相互作用相关的晚期结局和后果，以及2）经证实未感染的围产期治疗婴儿的晚期治疗效应。数据将包括病史、生活质量评估、体格检查、神经认知测试、临床和实验室评估、发病率和死亡率。研究将持续至儿童年满21岁或失访。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is a need to better assess both positive and negative late consequences of the various anti-HIV therapies administered to children. This study is designed to collect prospective, longitudinal data to identify 1)late outcomes and consequences related to HIV disease progression, treatment or prophylactic intervention, and/or interaction of HIV disease and therapy and 2) late treatment effects among perinatally treated infants proven to be uninfected. Data will include history, quality of life assessment, physical exam, neurocognitive testing, clinical and laboratory evaluations, morbidity, and mortality. The study will last until the child reaches his/her 21st birthday or is lost to follow-up.